نتایج جستجو برای: pyridopyrimidine 5 carbohydrazide
تعداد نتایج: 1216072 فیلتر نتایج به سال:
Ethyl naphtho[2,1-b]furan-2-carboxylate (2) on reaction with hydrazine hydrate in presence of acid catalyst in ethanol medium affords naphtho[2,1-b]furan-2-carbohydrazide (3). The reaction of substituted acetophenones (4a-c) with aromatic aldehydes (5a-e) produces chalcones (6a-o) via the Claisen condensation. The reaction of naphtho[2,1-b]furan-2-carbohydrazide (3) with chalcones (6a-6o) in pr...
As a potential solution to concerns on sustainable energy, the wide spread commercialization of fuel cell has long been hindered by limited reserves and relatively high costs of metal catalysts. 3D graphene, a carbon-only catalyst prepared by reduction of carbon monoxide with lithium oxide, is found to electrochemically catalyze carbohydrazide oxidation reaction efficiently. A prototype of a co...
AIM Platelets plays a central role in hemostatic processes and consequently are similarly involved in pathological processes, such as arterial thrombosis and atherosclerosis. Herein we described the synthesis, antiplatelet profile and structure-activity relationship (SAR) of a new series of N'-substitutedphenylmethylene-1H-pyrazolo[3,4-b]pyridine-carbohydrazide derivatives (3a-3k). METHODS Th...
The condensation reaction between carbohydrazide and salicylaldehyde in different solvents gave mono(salicylidene)carbohydrazide (1). The structure of 1 in solution has been determined by using experimental (NMR and UV spectroscopies and Mass spectrometry) and quantum chemical (DFT) methods. It has been demonstrated that 1 adopts the hydroxy-one tautomeric form which is in accordance with previ...
A series of new N ′ -[(alkyl/aryl)sulfonyl]-1-(phenylsulfonyl)piperidine-4-carbohydrazide derivatives were synthesized. Starting from ethyl piperidine-4-carboxylate (a), first ethyl 1-(phenylsulfonyl)piperidine-4-carboxylate (1), second 1-(phenylsulfonyl)piperidine-4-carbohydrazide (2), and finally N ′ -[(alkyl/aryl)sulfonyl]-1-(phenylsulfonyl)piperidine4-carbohydrazides (4a–n) were synthesized...
BACKGROUND We have identified a series of compounds that inhibit protein synthesis in bacteria. Initial IC50's in aminoacylation/translation (A/T) assays ranged from 3 to14 μM. This series of compounds are variations on a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol scaffold (e.g., 4H-pyridopyrimidine). METHODS Greater than 80 analogs were prepared to investigate the structure-activity relat...
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