A simple one-pot and efficient synthetic method for the synthesis of pyrimido[4,5-c]pyridazine by a multicomponent reaction. The compounds are study their inhibitory activities towards AKT1 pathways using in silico method. It was found that all have binding energy lower than -7.9 kcal/mol compound 3a is most active with -9.65 kcal/mol, which been performed autodock vina.

Introduction of ester groups into positions 4 and 5 of 3-iodopyridazines (1,2) by redox decomposition of the oxyhydroperoxide of ethyl pyruvate in a sulfuric acid/toluene two-phase system affords trifunctional pyridazine building blocks (3,4a) in a single step. Iodoarenes and -hetarenes are known as useful synthons for C-C bond formation by palladium-catalyzed cross-coupling reactions. In the p...

We have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important buildin...

The asymmetric unit of the title compound, C(9)H(11)ClN(4), contains two virtually planar mol-ecules that differ in conformation about the bond connecting the hydrazine and pyridazine units. The 3-chloro-6-hydrazinylpyridazine and cyclo-pentane groups are oriented at dihedral angles of 4.5 (3) and 8.8 (4)° in the two mol-ecules. In the crystal, the mol-ecules form a one dimensional polymeric st...