نتایج جستجو برای: pyrazolones

تعداد نتایج: 119  

Journal: :Bioorganic & medicinal chemistry 2012
Milan Urban Martin Vlk Petr Dzubak Marian Hajduch Jan Sarek

The aim of this work was to synthesize a set of heterocyclic derivatives of lupane, lup-20(29)-ene, and 18α-oleanane, and to investigate their cytotoxic activities. Some of those heterocycles were previously known in the oleanane (allobetulin) group; however, to our knowledge the syntheses and biological activities of lupane heterocycles have not been reported before. Starting from betulin (1) ...

Journal: :Organometallics 2023

Structural and electronic factors are crucial to rationalize the different N,O or N,N chelating coordination of pyrazolones containing a pyridine ring. The reactivity proligand 3-phenyl-1-(pyridin-2-yl)-5-pyrazolone (HLpy,ph) with (arene)Ru(II) fragment was explored. Neutral ionic complexes were obtained fully characterized, also by X-ray diffraction, revealing ligand coordinate in an unusual N...

Journal: :International archives of allergy and immunology 2016
Eva Rebelo Gomes Luísa Geraldes Ângela Gaspar Daniela Malheiro Susana Cadinha Carmo Abreu Marta Chambel Eugénia Almeida Emília Faria

BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical history, and provocation tests are considered the gold standard for diagnosis. Skin tests have some value to study reactions to pyrazolones. Laboratory investigations are mostly used for research purposes. Different pheno...

Journal: :Journal of investigational allergology & clinical immunology 2008
O Quercia F Emiliani F G Foschi G F Stefanini

BACKGROUND Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are a frequently reported problem due to the fact that these molecules are often used for control of pain and inflammation. Although the use of selective inhibitors of cyclooxygenase (COX) 2 helps to prevent some of these adverse reactions, they can have cardiac side effects when taken for prolonged periods. Here we r...

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