Decreased blood supply, high sugar level, and a possibility of bacterial infection in diabetic wounds pose risk for limb loss mortality. Therefore, proper wound care is needed to improve the quality life patients. Vitex trifolia L (Legundi) extract reported have antibacterial antioxidant activity that enhances cell proliferation migration. The antimicrobial hemostatic properties chitosan film a...

Solid polymer-drug dispersions are used to prepare and stabilize amorphous forms of poorly soluble drugs as a means of improving drug solubility, dissolution and bioavailability. Despite many reports on this subject, solid dispersion dissolution mechanisms have not been well understood. An early study was reported by Simonelli, Mehta and Higuchi (SMH) in 1969 and has served as a model for dispe...

The current research focused on screening and finding the significant independent variables in stavudine loaded tablet, followed by optimizing best formulation using central composite design. objective of study to develop controlled release tablet utilizing reduced factorial design, optimization technique as well characterization prepared tablets. Preliminary trial batches were different grades...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

Background and objectives: Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil which has shown several therapeutic effects. There are few works regarding the formulation of essential oils as oral solid dosage forms due to their liquid nature, stability and technical problems. The aim of this study was to combine the solid-d...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated  by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation  and direct compression. Discs were standardized based on the total phenol.  Properties such as in vi...

In order to develop a kind of APAP double-release pellet capsules, which was prepared with the manual filling method, immediate and sustained release pellets certain proportion were by fluidized bed coating extrusion spheroidization process, respectively. It founded that both immediate-release sustained-release had smooth round surfaces. The particle size distribution ranged evenly from 16 35 m...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

Group 1 capsular polysaccharides (CPSs) of Escherichia coli and some loosely cell-associated exopolysaccharides (EPSs), such as colanic acid, are assembled by a Wzy-dependent polymerization system. In this biosynthesis pathway, Wza, Wzb, and Wzc homologues are required for surface expression of wild-type CPS or EPS. Multimeric complexes of Wza in the outer membrane are believed to provide a cha...