Circulation. 2005;111(23):3135-3140. 19. Horai R, Nakajima A, Habiro K, et al. TNFis crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice. J Clin Invest. 2004; 114(11):1603-1611. 20. Shepherd J, Little MC, Nicklin MJ. Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. J Invest Dermatol. 2004;122(3):665669. 21. Nakae...

Impetigo herpetiformis (IH) is a rare pustular dermatosis with unknown aetiology, typically occurring during pregnancy. Based upon a similar clinical and histological presentation, i.e. spongiform accumulation of polymorphonuclear leucocytes in the stratum corneum, several authors consider IH as a variant of generalized pustular psoriasis (GPP), while others state that IH is a separate entity. ...

Psoriasis is a systemic, chronic, immunologically mediated disease, with significant genetic and environmental influences. It affects from 1 to 3% of the world population. Recently, the relation between psoriasis and different comorbidities, particularly metabolic syndrome, has become extremely relevant. Uveitis is characterized by a process of intraocular inflammation resulting from various ca...

A 27-year-old nulligravida woman without a history of dermatosis was hospitalized for threatened preterm labor at 29 weeks' gestation; therefore, continuous infusion of ritodrine hydrochloride was started. At 31 weeks' gestation, erythematous plaques appeared and spread over the body surface; therefore, a topical steroid preparation was applied. At 32 weeks' gestation, the eruptions developed i...

OBJECTIVE To analyze the association of psoriasis with smoking habits and alcohol consumption before first diagnosis by a dermatologist. DESIGN A multicenter case-control study. Interviews were conducted by trained medical investigators using a structured questionnaire. SETTING Outpatient services of 10 general and 10 teaching hospitals in northern and southern Italy. SUBJECTS Patients wi...

We describe the case of a young male affected by chronic pustular psoriasis of the lips that remained the only manifestation of acrodermatitis continua of Hallopeau (ACH) for years before the onset of the characteristic hand lesions.

weak response after 10 days of ciclosporin and the immediate need to control the systemic disease. After 4 weeks, the patient was free of pustules but a slight erythema was still present. At week 14, the patient was free of lesions, and, after the 5th infusion, she requested the suspension of infliximab. Efa lizumab was reintroduced with the maintenance of the excellent results (PASI-100) until...