This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with infrared (IR), ¹H-NMR and 13C-NMR spectroscopic methods, and high resolution mass spectroscopy (...

Lichen, Parmotrema stuppeum (P. stuppeum) was successively extracted with benzene and acetone. Both the extracts were fractionated on 1% oxalic acid impregnated silica gel column to obtain four phenolic compounds. The structures of compounds were identified by 1H and 13C NMR spectra as methyl orsenillate, orsenillic acid, atranorin and lecanoric acid respectively. Antioxidant activity of benzen...

phenolic and flavonoid compounds are secondary metabolites of plants which possess various activities such as anti-inflammatory, analgesic, anti-diabetes and anticancer effects. it has been established that these compounds can scavenge free radicals produced in the body. because of this ability, not only the plants containing phenolic and flavonoid compounds but also, the pure compounds are use...

Cyclin-dependent kinase 2 (CDK2), a member of Cyclin-dependent kinases (CDKs), plays an important role in cell division and DNA replication. It is regarded as a desired target to treat cancer and tumor by interrupting aberrant cell proliferation. Compared to lower subtype selectivity of CDK2 ATP-competitive inhibitors, CDK2 allosteric inhibitor with higher subtype selectivity has been used to t...

UTGe compounds absorb hydrogen up to 2 H atoms/f.u., which has a dramatic impact on the 5f magnetism. The TC value of UCoGe increases to 50 K. Magnetic susceptibility of spin fluctuator UFeGe markedly increases. For ferromagnetic URhGe only α-hydride could be obtained with moderate increase of TC and spontaneous moment. The α-hydride of UCoGe is surprisingly paramagnetic despite of a small volu...

the most current pursuit algorithms for moving targets which are presented so far in the literatureare pure pursuit and pure rendezvous navigations. recently, one of the present authors has introduced ageometric model for the pure pursuit navigation algorithm. here, in this paper, we study a new algorithm forthe pursuit navigation problem which is a combination of both of the above algorithms. ...

Highly crystalline and pure lithium metasilicate (Li2SiO3) and lithium disilicate (Li2Si2O5) nanomaterials were synthesized by hydrothermal method and characterized by PXRD technique. The changes in the morphology and particle size of the synthesized nanomaterials with reaction time were investigated using SEM technique. The UV-Vis and photoluminescence spectra of the compounds were studied. Th...

in this paper‎, ‎we introduce the notion of $(m,n)$-‎algebr‎aically compact modules as an analogue of algebraically‎ ‎compact modules and then we show that $(m,n)$-algebraically‎ ‎compactness‎ ‎and $(m,n)$-pure injectivity for modules coincide‎. ‎moreover‎, ‎further characterizations of a‎ ‎$(m,n)$-pure injective module over a commutative ring are given‎.

INTRODUCTION S. aureus is a Gram positive bacterium which is responsible for a wide range of infections. This pathogen has also the ability to adhere to biotic or abiotic surface such as central venous catheter (CVC) and to produce a biofilm. The aim of this study was to evaluate the effect of hexadecyltrimethyl ammonium bromide (HTAB) and Hexadecylbetainate chloride (HBC) on Staphylococcus aur...

Highly crystalline and pure lithium metasilicate (Li2SiO3) and lithium disilicate (Li2Si2O5) nanomaterials were synthesized by hydrothermal method and characterized by PXRD technique. The changes in the morphology and particle size of the synthesized nanomaterials with reaction time were investigated using SEM technique. The UV-Vis and photoluminescence spectra of the compounds were studied. Th...