In this work, we investigate the behavior of the pulsatile blood flow in the system of human coronary arteries. Blood is modeled as an incompressible non-Newtonian fluid. The transient phenomena of blood flow through the coronary system are simulated by solving the three dimensional unsteady state Navier-Stokes equations and continuity equation. Distributions of velocity, pressure and wall shea...

OBJECTIVES We hypothesized that recognition of systolic flow reversal (pulsatile flow) after thrombolytic administration on coronary angiography is associated with angiographic and electrocardiogram findings reflecting impaired myocardial perfusion, as well as poorer clinical outcomes. BACKGROUND Reversal of systolic flow on Doppler velocity wire recordings has been associated with impaired t...

Pulsatile motion of blood in a circular tube of varying cross-section has been developed by considering slip flow at the tube wall and the blood to be a non- Newtonian biviscous incompressible fluid. The tube wall is supposed to be permeable and the fluid exchange across the wall is accounted for by prescribing the normal velocity of the fluid at the tube wall. The tangential velocity of the fl...

Computational models of cerebral aneurysm thrombosis are designed for use in research and clinical applications. A steady flow assumption is applied many these models. To explore the accuracy this a pulsatile-flow thrombin-transport computational fluid dynamics (CFD) model, which uses symmetrical idealized geometry, was developed. First, steady-flow model developed validated using data from an ...

Enhancement of heat and mass transfer and decrease of energy dissipation are great necessities of the evolution of fluid flow devices. Utilizing oscillatory or pulsatile fluid flow for periodic disturbing of velocity and thermal boundary layers is one of the methods with exciting results. Passive methods of generating oscillatory flow are preferred to active methods because of simplicity, no ne...

The onset of nonpulsatile cardiopulmonary bypass is known to deteriorate microcirculatory perfusion, but it has never been investigated whether this may be prevented by restoration of pulsatility during extracorporeal circulation. We therefore investigated the distinct effects of nonpulsatile and pulsatile flow on microcirculatory perfusion during on-pump cardiac surgery. Patients undergoing co...

The cardiovascular system is an internal flow network with multiple branches in which three-dimensional and pulsatile blood flow circulates. We propose a new paradigm of simulation-based biomedical engineering, which is designed as a useful means for predictive medicine. In order to achieve this paradigm a global computational modeling of cardiovascular blood flow is highlighted and some prelim...

The ears of rabbits were perfused with defibrinated rabbit's blood in such a way that pulsation could be imparted to the perfusate or withheld from it at will. In the absence of pulsation there was almost no lymph flow, whereas when it was present lymph flow was rapid despite the fact that the "systolic" pressure of the perfusate never exceeded the constant pressure in the non-pulsatile instanc...

AIMS Aberrant retinal blood flow is a hallmark of various retinopathies and may be a causative factor in the pathology associated with these conditions. We examined the effects of pulsatile flow on bovine retinal endothelial cell (BREC) and bovine retinal pericyte (BRP) apoptosis and proliferation. METHODS AND RESULTS Co-cultured BRECs and BRPs were exposed to low (0.3 mL/min) or high (25 mL/...