Nude (Nu/Nu) and heterozygous (NU/+) mice were infected with Actinomyces israelii serotype I by either intranasal instillation or intravenous injection. Lung clearance data and 50% lethal dose values indicated that T-lymphocytes were not necessary for pulmonary clearance or prevention of systemic actinomycosis. However, T-lymphocyte deficiency may play a role in the localized cervicofacial form...

Antibody-mediated clearance of respiratory syncytial virus from cotton rat pulmonary tissues occurs in the absence of complement and in the absence of the Fc portion of the immunoglobulin G molecule, suggesting that complement-independent, cell-independent neutralization is the major mechanism of clearance.

Allergic rhinitis in children is not an uncommon disease in India. Our objective was to evaluate the effect of allergic rhinitis on nasal mucociliary clearance. The nasal mucociliary clearance time (NMC) was studied using Andersen’s saccharin method in fifty controls and fifty age and sex matched patients of allergic rhinitis. The nasal mucociliary clearance time in healthy controls was found t...

Although T cells are critical for host defense against respiratory fungal infections, they also contribute to the immunopathogenesis of Pneumocystis pneumonia (PcP). However, the precise downstream effector mechanisms by which T cells mediate these diverse processes are undefined. In the current study the effects of immune modulation with sulfasalazine were evaluated in a mouse model of PcP-rel...

This study was conducted to assess esophageal function and pulmonary resistance changes with esophageal acidification in patients with COPD. Twelve patients with COPD and a mean age of 55.6 years were studied. Each patient underwent standard esophageal manometry, 24-h ambulatory pH testing, esophageal acid clearance evaluation during sleep, and an assessment of pulmonary resistance with and wit...

Abstract Circadian rhythms form an anticipatory system wherein various aspects of cellular physiology oscillate across a 24hrs period; these have been known to modulate facets immunity. We previously shown that mice infected with Influenza A virus (IAV) at dusk had 3-fold higher mortality than littermates dawn--a hallmark circadian regulation. This time-of-day specific protection was lost when ...

Cystic fibrosis (CF) is a chronic disorder characterized by acute pulmonary exacerbations that comprise increased cough, chest congestion, increased mucus production, shortness of breath, weight loss, and fatigue. Typically, severe episodes are treated in the inpatient setting and include intravenous antimicrobials, airway clearance therapy, and nutritional support. Children with less-severe fi...