The significance of physical exercise and attempts of detecting early pulmonary fibrous lesions using resultant parameters were described in cases with pulmonary fibrosis and pneumoconiosis. Although the usefulness of A-aDo2 has been pointed out long before the use of the respiratory index (A-aDoz/Pa02 x100) instead of A-aDo2 itself was thought to be more effective. In relation to this, the cha...

We previously reported in weanling guinea pigs raised at high altitude (HA; 3,800 m) an elevated lung diffusing capacity estimated by morphometry from alveolar-capillary surface area, harmonic mean blood-gas barrier thickness, and pulmonary capillary blood volume (Vc) compared with litter-matched control animals raised at an intermediate altitude (IA; 1,200 m) (Hsia CCW, Polo Carbayo JJ, Yan X,...

Derangement of pulmonary function following myocardial infarction is related to the severity of hemodynamic dysfunction. Abnormalities of pulmonary function appear even in patients without clinical or radiologic evidence of congestive failure. There is a reduction in vital capacity and rates of air flow. There is evidence for dysfunction of “small airways” and diminished ventilation to dependen...

While the pulmonary diffusing capacity is now accepted as an important test of lung function, comparatively little application of the test has been made in patients suffering from cardiac disorders. Bates, Boucot, and Dormer (1955) were the first to describe a simple and reliable means for estimating gaseous diffusion, using the steady state carbon monoxide technique. MacNamara, Prime, and Sinc...

The purpose of this study was to determine whether there are any consistent spirometric or Dsb findings in patients with LV dysfunction characterized by a clinical diagnosis of CHF and an EF less than 40 percent. We performed spirometry and Dsb in 34 patients, and found that EF correlated only with Dsb. When we separated the patients into those with rales and those without, Dsb correlated stron...

The degree of lung distension during quiet respiration, the so-called respiratory position or resting expiratory level, is essentially determined by a balance between the passive forces produced by the thoracic wall and the active forces due to the elastic properties of the lung. Therefore the interplay of these forces has a direct role in determining the extent of the functional residual capac...