Static light-scattering (LS) detection can determine the molecular weight (MW) of polymers eluted with size-exclusion chromatography (SEC) without using any standards when the differential refraction index (RI) of solutes are obtained. On the other hand, the noisy chromatographic signal peak acquired using a static LS detector often causes difficulty in peak-width recognition. This disadvantage...

Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microscopy and mechanical analysis were performed. The polysaccharide concentration directly influenced vapor per...

Ondansetron is a highly selective serotonin (5-HT3) receptor blocker which inhibits serotonin to bind with serotonin 5-HT3 receptors and hence prevent the vomiting reflex induced by serotonin. This work aimed to develop rapid dissolving films of ondansetron for the treatment of chemotherapy induced nausea and vomiting. Rapid dissolving films were prepared by solvent casting method using pullula...

Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were char...

This article reviews previous studies on micellar structures formed by hydrophobically modified polysaccharides in aqueous solutions static and dynamic light scattering, small angle X-ray neutron fluorescence from pyrene solubilized polymer solution. The experimental results are consistently explained the full or loose flower necklace model for pullulan bearing octenyl groups amylose dodecyl ra...

Fast-dissolving films (FDFs) were prepared from natural polysaccharides, such as pullulan, without heating, controlling the pH, or adding other materials. The release profiles of model drugs from the films were investigated. In the absence of a drug, the casting method and subsequent evaporation of the solvent resulted in the polysaccharide forming a circular film. The presence of drugs (both t...