WORCESTER ET AL. (1) ARE TO be praised for their recent contribution to an understanding of the pathophysiology of hypercalciuria. However, we would like to call their attention to potential pitfalls in their interpretation of three of their data. 1) They state that the overlap between normal subjects (N) and idiopathic hypercalciuria calcium stone formers (IHSF) is minimal with respect to frac...

To define the structural requirements of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor necessary for activation of phospholipase C (PLC), receptors with random mutations in their second cytoplasmic loop were synthesized, and their properties were assessed. A mutant in which the wild type (WT) rat PTH/PTHrP receptor sequence EKKY (amino acids 317-320) was replaced with DSEL ...

the impact of pgf2? on total proteins, free amino acids and the amino transferases in the gonads of silkworm, bombyx mori l. were investigated in the present experiment. the effect of pgf2? resulted in increase in the total protein and free amino acid contents in the gonads of silkworm larvae indicating improved structural and dynamic levels of organization. the enhanced activity levels of amin...

Quorum sensing controls the luminescence of Vibrio fischeri through the transcriptional activator LuxR and the specific autoinducer signal produced by luxI. Amino acid sequences of these two genes were analyzed using bioinformatics tools. LuxI consists of 193 amino acids and appears to contain five α-helices and six ß-sheets when analyzed by SSpro8. LuxI belongs to the autoinducer synthetase fa...

In lb is research, adsorption of some amino acids and their complenation with manganese (II) ion on carbonnanotube (MWCNT) by using of four relations Langmuir, Freundlich. Temkin and Harkins -Jura imitherms wasinvestigated. From this relations. Freudlich and Temkin relations predict good equilibrium diagram in, isothermcondition. we could compute the theoretical constants by excel software. Hy ...

The calcium (Ca(2+))-sensing receptor (CaR) belongs to family C of the G-protein coupled receptors (GPCRs). The receptor is activated by physiological levels of Ca(2+) (and Mg(2+)) and positively modulated by a range of proteinogenic L-alpha-amino acids. Recently, several synthetic allosteric modulators of the receptor have been developed, which either act as positive modulators (termed calcimi...

it has been reported that neurons in the vl pag projecting to nucleus raphe magnus (nrm) utilize excitatory amino acids as neurotransmitter. this projection plays an important role in the descending pain modulatory system. in order to determine the role of this pathway in pain perception, male rats received unilateral injection of ibotenic acid stereotaxically. for lesioning vl pag, unilateral ...

the adsorption of a number of amino acids on a defected single-walled carbon nanotube (swcnt) isinvestigated by using the density-functional theory (dft) calculations. the adsorption energies andequilibrium distances are calculated for various configurations such as amino acid attaching to defectsites heptagon, pentagon and hexagon in defective tube and also for several molecular orientationswi...

fish larvae have a high requirement of amino acid (aa) for energy production and growth. this study was aimed to increase knowledge of aa profile during feral carp larval ontogeny and estimate larval aa requirements. larvae were collected randomly at 1, 3, 7, 11, 15, 19, 26 and 33 days post hatch for growth and aa analysis. the composition of total aa changed significantly during ontogeny. the ...