Previous studies have shown that inhibition of the proto-oncogene c-myb inhibits neointimal formation in various animal models. However, the temporal and spatial expression of c-Myb in the vessel wall after injury is not known, and the mechanism of action of antisense oligonucleotide (AS-ODN-c-myb) inhibition remains unclear. One potential effect of cell cycle dysregulation by inhibition of c-m...

Accepted 15 September 1995 In 1980, De Wood et al first reported angiographic evidence of a high incidence of totally occluded or critically stenosed infarct-related arteries in the early hours of acute myocardial infarction.' Such findings prompted the use of intracoronary and later intravenous streptokinase therapy. It is now well established that after acute myocardial infarction, the earlie...

Although primary angioplasty (PTCA) achieves reper-fusion in acute myocardial infarction (AMI) more readily than thrombolysis without the risk of intracranial haemorrhage , economic and logistic issues limit its applicability. 1 Most patients with AMI present to hospitals without cardiac catheterisation facilities, let alone PTCA expertise. The safety and feasibility of the emergency transfer o...

background: practice of interventional cardiology procedures such as coronary angiography (ca) and percutaneous transluminal coronary angioplasty (ptca) has largely increased in recent years and is now changing to a matter of routine in many hospitals. the purpose of this study was to measure skin and organ doses in patients undergoing ca and ptca and to find a probable relation with cardiologi...

of the angioplasty segment between the concentric and eccentric lesion subgroups was not significant (analysis of variance) at any time after PTCA. The degree of vasoconstriction observed in the angioplasty segment of both the concentric and eccentric lesion subgroups were significantly greater than that of the control segment at 15 and 30 minutes after PTCA (p CO.01 and <0.005, respectively). ...

To determine risk factors for restenosis, we studied 998 patients who underwent elective coronary angioplasty (PTCA) to native coronary arteries between July 1980 and July 1984. Restenosis, defined as a luminal narrowing of greater than 50% at follow-up, was present in 302 patients (30.2%). Univariate analysis of 29 factors revealed seven factors related to restenosis: vessel dilated (circumfle...

OBJECTIVE To compare the early and late outcomes of primary percutaneous transluminal coronary angioplasty (PTCA) with fibrinolytic treatment among diabetic patients with acute myocardial infarction (AMI). DESIGN Retrospective observational study with data obtained from prospective registries. SETTING Tertiary cardiovascular institution with 24 hour acute interventional facilities. PATIEN...

AIM To investigate the effect of abciximab on microvascular integrity and left ventricular (LV) functional recovery in patients with acute myocardial infarction (MI) treated by primary coronary angioplasty (PTCA). METHODS AND RESULTS Thirty-one patients (27 males; age 39-76 years) with first, acute MI (<6 h after onset) were randomized to receive either abciximab+primary PTCA (n=17) or primar...

AIMS The German Angioplasty Bypass Surgery Investigation was designed to compare symptomatic efficacy and safety of percutaneous coronary balloon angioplasty (PTCA) with coronary artery bypass surgery (CABG) in patients with symptomatic multi-vessel disease. This follow-up study was performed to determine the long-term outcome of patients following these interventions. METHODS AND RESULTS Fro...

Objective: To investigate whether enhanced oxidant stress in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) is associated with a higher concentration of non-high density lipoprotein (HDL) cholesterol at baseline, and whether this contributes to the inflammatory reaction and luminal renarrowing after PTCA. Design: An ex vivo and in vitro study of 46 patients who underw...