A 67-year-old woman with Alzheimer’s disease was administered 5 mg/day donepezil for approximately three years. The patient exhibited acute confusion, global impairment of cognition with disorientation, sleep disturbance, psychomotor agitation, hallucinations and delusions due to delirium at night. She was then administered 8 mg/day blonanserin for approximately one month in addition to donepez...

Little is known regarding the management of psychotic disorders in NARP syndrome. We report the case of a 30 year-old Caucasian male, born from healthy unrelated parents. During his first year, he presented cerebellar ataxia with pyramidal syndrome. Sequencing his leukocyte and urinary mtDNA detected a heteroplasmicmutation (95%) in the MTATP6 gene (m.8993TNC) [1]. At 28 years, he presented a p...

Major depression with psychotic features, while fairly common, is frequently misdiagnosed. Symptoms seen in these patients are those of an overall severe depressive disorder with psychomotor impairment (retardation or agitation), guilt, suicidal preoccupation, and neuropsychological impairment. A number of biological characteristics and behavioral symptoms are specific to patients suffering fro...

OBJECTIVES To compare chart- and interview-based methods for identification of delirium. DESIGN Prospective cohort study. SETTING Two academic medical centers. PARTICIPANTS Individuals aged 70 and older undergoing major elective surgery (N = 300) (majority orthopedic surgery). MEASUREMENTS Participants were interviewed daily during hospitalization for delirium using the Confusion Assess...

BACKGROUND Major depressive episodes with psychotic features are more common in bipolar disorder than in major depressive disorder; however, there is little information on the optimal treatment for bipolar depression with psychotic features. CASE PRESENTATION The patient was a 69-year-old man. At the age of 66, he was admitted to the hospital for the treatment of bipolar depression with psych...

BACKGROUND The evidence on the mechanisms of action of electroconvulsive therapy (ECT) has grown over the past decades. Recent studies show an ECT-related increase in hippocampal, amygdala and subgenual cortex volume. We examined grey matter volume changes following ECT using voxel-based morphometry (VBM) whole brain analysis in patients with severe late life depression (LLD). METHODS Elderly...

4-P-CHL0R0PHENYL-l-(3-p-fiuorobenzoylpropyl)-4-hydroxypiperidine (R. 1625, Haloperidol) is a new compound synthesized by Janssen et al. (1959) and reported to have biological properties similar to those of the phenothiazines at a much lower dosage level. One difference, however, was a greater tendency to potentiate pentobarbitone hypnosis. Von Eiff and Jesdinsky (1960) conducted a “¿ double b...

OBJECTIVE To investigate the association between aggression in the first 24 hours after admission and severity of psychopathology in psychiatric inpatients. METHODS This cross-sectional study included psychiatric patients admitted to Hospital Universitário de Santa Maria, in Santa Maria, southern Brazil, from August 2012 to January 2013. At their arrival at the hospital, patients were intervi...

BACKGROUND Refeeding syndrome is a rare and life-threatening pathology with polyvisceral manifestations occurring in severely malnourished patients. It is rarely described in adults with celiac disease. CASE PRESENTATION We report the case of a 28-year-old Tunisian woman followed up for celiac disease, who did not adhere to the gluten-free diet. She presented to our hospital with celiac crisi...

Interest in quality of life in mental health care has been stimulated by the deinstitutionalization of psychiatric patients as well as a parallel interest in understanding the scope of their daily lives. This study aims to investigate the socio-demographic and clinical variables related to low quality of life, using a cross-sectional design to evaluate quality of life by means of the QLS-BR sca...