AIM The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product. METHODS Data from an anonymous survey among 1770 pharmacy customers purchasing the combination product for treatment of own common cold symptoms underwent post-hoc descriptive analysis. Scores of symptoms typically res...

Chloroephedrine is an intermediate and possible contaminant formed when methamphetamine is manufactured using ephedrine or pseudoephedrine as precursors. The purpose of this study was to determine whether this contaminant has biological activity and might contribute to methamphetamine-induced cardiovascular toxicity. In conscious rats, the (-) and (+) isomers of chloroephedrine (0.1 and 1.0 mg/...

Volume 22, Issue 7 April 2007 1 During the peak of cough and cold season millions, of Americans find themselves searching through the cold medicine section of the neighborhood store in an attempt to relieve nasal stuffiness and sinus pressure. Until recently, the choice included with the ingredient pseudoephedrine found in over 700 cough and cold remedies. Pseudoephedrine (Sudafed ® ) , phenylp...

BACKGROUND AND PURPOSE Phenylpropanolamine (PPA) and pseudoephedrine are sympathomimetics contained in over-the-counter cold preparations. A case-control study linked PPA use with hemorrhagic stroke in women. Twenty-two patients with stroke associated with use of these drugs are described. METHODS In a consecutive stroke registry since 1988, 22 patients had stroke associated with over-the-cou...

OBJECTIVES Restrictions on retail purchases of pseudoephedrine are one regulatory approach to reduce the social costs of methamphetamine production and use, but may impose costs on legitimate users of nasal decongestants. This is the first study to evaluate the costs of restricting access to medications on consumer welfare. Our objective was to measure the inconvenience cost consumers place on ...

Title of Thesis: BIOACTIVITY OF EPHEDRA: INTEGRATING CYTOTOXICITY ASSESSMENT WITH REAL-TIME BIOSENSING Kazuko Fukushima, Master of Science, 2004 Thesis Directed By: Dr. Y. Martin Lo, Department of Nutrition and Food Science Ephedrine-type alkaloids (ETA) are major active ingredients of Ephedra, a traditional Chinese medicinal herb used to treat asthma and nasal congestion. Until recently, large...

Complete discrimination of ephedrine and pseudoephedrine, both in solution and in the solid state, was achieved with a phosphonate cavitand receptor. The molecular origin of the epimer discrimination was revealed by the crystal structure of the respective complexes.

A method for identifying the enantiomers of N,O-di-trifluoroacetylated ephedrine (EP) and norephedrine (NE) and the enantiomers of pseudoephedrine (PEP) and pseudonorephedrine (PNE) in plasma was developed using chiral capillary gas chromatography-mass spectrometry (GC-MS) with selected ion monitoring (SIM). N,O-Di-trifluoroacethyl (TFA) derivatization was accomplished in a dried hydrochloride ...

Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test...

T he electrocardiogram shown in Figure 1 was read by the computer as arm-lead reversal. Th e computer reading went on to say that no further analysis would be attempted. Th is clearly is a programming mistake because the precordial leads make the diagnosis. Although we would estimate that 95% of electrocardiograms with negative P, QRS, and T waves in lead I are due to armlead reversal, a small ...