نتایج جستجو برای: prs

تعداد نتایج: 1779  

2008
Atul Adya John Dunagan Alec Wolman

Scale-out datacenter applications are of enormous commercial interest, yet they are frustratingly hard to build. A common design pattern is to locate most of the application logic in a middle tier of soft-state servers and to provide storage using a separate backend system. The Partitioning and Recovery Service (PRS) is an infrastructure service that makes it easier to build these middle tier a...

Journal: :Archives of disease in childhood 1991
T J Stephenson F Broughton Pipkin A C Elias-Jones

Concentrations of plasma renin (PRC) and plasma renin substrate (PRS) were measured during the first week of life in 52 infants born at less than 37 weeks' gestation (mean (SEM) gestation 30 (0.4) weeks, mean (SEM) birth weight 1.35 (0.08) kg). Both PRC (median 35, interquartiles 16.3, 94.5 ng/ml/hour) and PRS (median 2.3, interquartiles 1.3, 5.0 micrograms/ml) were raised compared with adults....

Journal: :JASIST 2013
Lutz Bornmann

Dear Sir, Instead of a relative mean citation rate, a percentile rank score (PRS) can be used in bibliometrics to generate a normalized citation impact for a paper. The use of a PRS is very advantageous, as no assumptions have to be made as to the distribution of citations in the reference set; that is, the scores are applicable also for the (usually) rightskewed distributions. To calculate the...

2013
Abhishek Kumar Mishra Maria Tsachaki Jens Rister June Ng Arzu Celik Simon G. Sprecher

The functionality of sensory neurons is defined by the expression of specific sensory receptor genes. During the development of the Drosophila larval eye, photoreceptor neurons (PRs) make a binary choice to express either the blue-sensitive Rhodopsin 5 (Rh5) or the green-sensitive Rhodopsin 6 (Rh6). Later during metamorphosis, ecdysone signaling induces a cell fate and sensory receptor switch: ...

Journal: :Molecular cancer therapeutics 2013
Shane A Olwill Christian Joffroy Hendrik Gille Elisa Vigna Gabriele Matschiner Andrea Allersdorfer Bradley M Lunde Jakub Jaworski James F Burrows Cristina Chiriaco Hans Jürgen Christian Martin Hülsmeyer Stefan Trentmann Kristian Jensen Andreas M Hohlbaum Laurent Audoly

Activation of the MET oncogenic pathway has been implicated in the development of aggressive cancers that are difficult to treat with current chemotherapies. This has led to an increased interest in developing novel therapies that target the MET pathway. However, most existing drug modalities are confounded by their inability to specifically target and/or antagonize this pathway. Anticalins, a ...

2017
Hon-Cheong So Pak C. Sham

Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over a range of p-value thresholds, which are often chosen arbitrarily. The predict...

2018
Claire Hian Tzer Chan Prabhakaran Munusamy Sau Yeen Loke Geok Ling Koh Audrey Zhi Yi Yang Hai Yang Law Chui Sheun Yoon Chow Yin Wong Wei Sean Yong Nan Soon Wong Raymond Chee Hui Ng Kong Wee Ong Preetha Madhukumar Chung Lie Oey Gay Hui Ho Puay Hoon Tan Min Han Tan Peter Ang Yoon Sim Yap Ann Siew Gek Lee

Genome-wide association studies (GWAS) have proven highly successful in identifying single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. The majority of these studies are on European populations, with limited SNP association data in other populations. We genotyped 51 GWAS-identified SNPs in two independent cohorts of Singaporean Chinese. Cohort 1 comprised 1294 BC cas...

Journal: :Cell 2003
Mathias F. Wernet Thomas Labhart Franziska Baumann Esteban O. Mazzoni Franck Pichaud Claude Desplan

Different classes of photoreceptors (PRs) allow animals to perceive various types of visual information. In the Drosophila eye, the outer PRs of each ommatidium are involved in motion detection while the inner PRs mediate color vision. In addition, flies use a specialized class of inner PRs in the "dorsal rim area" of the eye (DRA) to detect the e-vector of polarized light, allowing them to exp...

2016
Osamu Ito Masaharu Mitsugi Minako Ito Tomoyuki Yano Takeshi Kawazoe Noriko Uemura

1 Osamu Ito, MD, PhD Department of PRS and Medical Check-up Centre Yokohama City Minato Red Cross Hospital Shinyamashita, Naka-ku, Yokohama Kanagawa, Japan Masaharu Mitsugi, DDS, PhD Department of OMFS Kochi Health Sciences Centre Ike, Kochi, Kochi, Japan Minako Ito, MD, PhD Tomoyuki Yano, MD, PhD Department of PRS and Medical Check-up Centre Yokohama City Minato Red Cross Hospital Shinyamashit...

Journal: :Educational Technology & Society 2013
Chu-Chen Rosa Yeh Yu-Hui Tao

To address four issues observed from the latest Personal Response System (PRS) review by Kay and LeSage (2009), this paper investigates, through a systematic research, how the derived benefits and challenges of PRS affect the satisfaction and continuance intention of college students in Taiwan. The empirical study samples representative college students enrolled in three universities from each ...

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