Protein secondary structure prediction is a problem related to structural bioinformatics which deals with the prediction and analysis of macromolecules i.e. DNA, RNA and protein. It is an important step towards elucidating its three dimensional structure, as well as its function. Secondary structure of a protein can be predicted from its primary structures i.e. from the amino

MOTIVATION The precise prediction of one-dimensional (1D) protein structure as represented by the protein secondary structure and 1D string of discrete state of dihedral angles (i.e. Shape Strings) is a prerequisite for the successful prediction of three-dimensional (3D) structure as well as protein-protein interaction. We have developed a novel 1D structure prediction method, called Frag1D, ba...

The automatic assignment of protein secondary structure from three dimensional coordinates is an essential step in the characterization of protein structure. <span style="font...

Article history: Received 26 Sept. 2012 Accepted 30 Sept. 2012 Available online 01 October 2012 The prediction of protein folding is important because the structure of a protein is related to its function. The study of protein structure therefore produces valuable practical benefits for medicine, agriculture and industry. The understanding of enzyme function allows the design of drugs which inh...

administering growth hormone increases growth rate of cultured fish. the aim of this study was isolation and synthesize of persian sturgeon gh cdna. the total rna was extracted from pituitary gland of persian sturgeon and cdna was synthesized. the full-length cdna sequence of persian sturgeon contains a 645 nucleotide open reading frame, which encoding a 214 amino acid residues. the position of...

Protein secondary structure prediction is a fundamental step in determining the 3D structure of a protein. In this paper, a new method for predicting protein secondary structure from amino acid sequences has been proposed and implemented. Cuff and Barton 513 protein data set is used in training and testing the prediction methods under the same hardware, platforms, and environments. The newly de...

background: boophilus tick is responsible for the transmission of some pathogens (types of germs) and the reduction of fertility in cattles. tropomyosin protein plays an important role in regulating actin function, immune and allergic reactions and vaccine production. objectives: accurate identification of antigenic determinants (epitopes) is difficult, time consuming and not economic, thus we ...

Predicting protein structure from amino acid sequence is one of the most important unsolved problems of molecular biology and biophysics.Not only would a successful prediction algorithm be a tremendous advance in the understanding of the biochemical mechanisms of proteins , but , since such an algorithm could conceivably be used to design proteins to carry out specific functions.Prediction of t...

Local structures predicted from protein sequences are used extensively in every aspect of modeling and prediction of protein structure and function. For more than 50 years, they have been predicted at a low-resolution coarse-grained level (e.g., three-state secondary structure). Here, we combine a two-state classifier with real-value predictor to predict local structure in continuous representa...

In this chapter, we discuss some approaches to the problem of protein structure prediction by addressing “simpler” sub-problems. The rationale behind this strategy is to develop methods for predicting some interesting structural characteristics of the protein, which can be useful per se and, at the same time, can be of help in solving the main problem. In particular, we discuss the problem of p...