A 79-year-old native American female with a history of diabetes mellitus, but no history of hepatic or renal disease, presented with anasarca and hypoalbuminemia. Laboratory tests for fecal alpha 1-antitrypsin and an indium III-labeled plasma transferrin nuclear scan revealed a protein-losing enteropathy. A serological test was positive for antinuclear antibody in a titer of 1:1250 with a homog...

Protein-losing enteropathy (PLE) is a debilitating potential complication of ulcerative colitis (UC). We report a case of PLE in a 26-year-old male patient with UC. The patient lost 50 pounds in the setting of a UC flare and was found to have an albumin level of 1.2 g/dl. Although the patient's UC was clinically controlled with steroids, the weight loss and hypoalbuminemia persisted with the pa...

We report an unusual case of a patient with Behçet's disease that developed protein-losing enteropathy due to intestinal lymphangiectasia.

AIMS Protein losing enteropathy is a serious complication of Fontan surgery. The aim of this study was to investigate gastro-intestinal protein loss in adults with congenital heart disease, both with and without Fontan surgery, and to correlate findings with systemic venous pressure. METHODS AND RESULTS Forty eight patients were studied. The first group included adult survivors of Fontan surg...

Waldmann T A. Protein-losing enteropathy. In: Card W I, Creamer B, eds. Modern trends in gastroenterology. Volume 4. London: Butterworth, 1970: 125-42. 2 Crossley J R, Elliott R B. Simple method for diagnosing protein-losing enteropathies. Br MedJ 1977; i: 428-9. 3 Bernier J J, Florent C, Desmazures C, Aymes C, L'Hirondel C. Diagnosis of protein-losing enteropathy by gastrointestinal clearance ...

The occurrence of exudative enteropathy in children with the nephrotic syndrome was first reported by Nussle et al. in 1961, but no intestinal pathology has previously been described in nephrotic children, whether with or without protein-losing enteropathy. The finding in small bowel biopsy specimens of intestinal lymphangiectasia, in 4 of 7 cases of nephrotic syndrome, suggests that this assoc...

BACKGROUND & AIMS METHODS Severe intestinal diseases observed in very young children are often the result of monogenic defects. We used whole exome sequencing (WES) to examine the genetic cause in a patient with a distinct severe form of protein losing enteropathy (PLE) characterized by hypoproteinemia, hypoalbuminemia, and hypertriglyceridemia. METHODS WES was performed at the Centre for App...