Although ginsenoside Rg3 has been shown to exert anticancer effects on a variety of malignancies, the and molecular mechanisms oesophageal cancer remain unclear. Therefore, these factors must be explored. Here, we analyzed effect cell proliferation migration, as well its apoptosis. Furthermore, detected downstream pathways that could act on. The results showed significantly inhibited migration ...

Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively st...

diabetic retinopathy is the lead among causes of blindness in north america. glucose-induced endothelial injury is the most important cause of diabetic retinopathy and other vascular complications. extracellular signal-regulated kinase 5 (erk5), also known as big mitogen-activated protein kinase 1 (bmk1), is a member of mitogen-activated protein kinases (mapk) family. physiologically, it is cri...

Background: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) is a natural polyphenolic compound derived from multiple medicinal plants with favorable anticancer activity. Methods: In this study, the mechanisms of PGG against gastric cancer were explored through network pharmacology and molecular docking. First, targets searched in Herbal Ingredients’ Targets (HIT), Similarity Ensemb...

Abdominal aortic aneurysm (AAA) involves the degradation of vascular fibres, and dilation rupture abdominal aorta. Hypoperfusion in walls due to stenosis vasa vasorum is reportedly a cause AAA onset induction adventitial ectopic adipocytes. Recent studies have reported that adipocytes are associated with both human hypoperfusion-induced animal models, highlighting pathological importance hypope...

The most common tumor affecting the head and neck is squamous cell carcinoma (HNSCC). characteristics of HNSCC include a rapid onset, lack early diagnosis, drug resistance, relapse systemic adverse effects, leading to inadequate prevention, diagnosis treatment. Notably, previous research suggests that there an association between S100 proteins HNSCC. S100A8, S100A9 S100A14 interfere with prolif...

The objective of this work was to identify novel downstream targets and evaluate the clinically interpretable significance long noncoding RNA KCNQ1OT1 expression in prognosis nasopharyngeal cancer. Patient with cancer (n=46) health volunteer (n=10) were collected from Beijing Army General Hospital (Beijing, China). Nasopharyngeal line 13-9B cells bought Chinese Academy Sciences Shanghai grown D...

lymphomas are solid tumors of immune system and non-hodgkin lymphomas (nhl) is the most prevalent lymphomas; with wide ranges of histological and clinical features, it is so difficult to identify them. herein, various bioinformatics tools (such as gene differential expressions, epigenetics and protein analysis) employed to find new treatment approach for nhl based on gene expression variation b...