In comparison with intense investigation of the structural determinants of protein folding rates, the sequence features favoring fast folding have received little attention. Here, we investigate this subject using simple models of protein folding and a statistical analysis of the Protein Data Bank (PDB). The mean-field model by Plotkin and coworkers predicts that the folding rate is accelerated...

1 Description LatFit allows the conversion of a protein’s full atom structure representation in Protein Data Bank (PDB) format into a coarse grained lattice model representation. This is done by 1. fitting the Cα-atoms to neighbored lattice positions for representation of the protein backbone. 2. If side chains are modelled, Cβ or the center of mass of the residues are fitted to neighbored posi...

There is an increasing realisation that the quality of the biomacromolecular structures deposited in the Protein Data Bank (PDB) archive needs to be assessed critically using established and powerful validation methods. The Worldwide Protein Data Bank (wwPDB) organization has convened several Validation Task Forces (VTFs) to advise on the methods and standards that should be used to validate al...