In the epithelium of secretory acini of the prostate two different cell types can be discriminated on the basis of localization, morphology, and degree of differentiation, the luminal and basal cells. The possibility of a developmental relationship between basal and luminal cells has been a subject of interest in several studies. According to the stem cell model at least three cell types, i.e.,...

Vitamin D Receptor (VDR) expression is implicated in human Prostatic Carcinoma (PC), but its role canine PC unclear. To investigate how VDR affected by age and castration healthy dogs it changes with PC, we evaluated prostates from 8-month-old (n = 5) or 6-year-old 8) intact males, 1-8-year-old castrated males 4) 8-15-year-old 7) performing histopathology, immunohistochemistry, ELISA. The resul...

Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA • @polymerase-• Ý • @ that • @is • @ synthesized • @ during • @ the • @ late • @G1 • @ phase through the S phase of cell proliferation. The expression of PCNA correlates strongly with cell proliferation. In the present study, employing NC-012, which is an anti-human PCNA monoclonal antibody, we performed immunohistochemica...

Malignant prostatic carcinoma, a major cause of cancer mortality in males, most often metastasizes to secondary sites in bone. Frequently, the growth rate of the secondary tumor in bone marrow is considerably greater than that of the slowly growing primary prostatic tumor. We now report that two lines of human prostatic carcinoma cells proliferate in response to conditioned media from unstimula...

Retraction artifacts are well known phenomenon in diagnostic surgical pathology for a long time but they were usually considered as artificially produced tissue alteration. Some recent studies of retraction artifact in different tumors have focused on its diagnostic and/or prognostic role. Their presence in prostatic carcinoma may be used in diagnostic and prognostic purposes. Peritumoral retra...

The diagnosis of prostatic carcinoma (Pca) on routine biopsies may be challenging, and to date the commonly used marker to distinguish prostate carcinoma from benign prostatic lesions has been High Molecular Weight-Cytokeratin (HMW-CK). However, the antigen of HMW-CK is susceptible to the effect of formalin fixation and causes frequent loss or patchy staining in the obviously benign glands. Mor...

The importance of polyamines in prostatic growth and differentiation has prompted studies to evaluate the clinical relevance of the ornithine decarboxylase/polyamine system in prostatic cancer. These studies show that differences in biological behaviour of prostatic (cancer) cells are associated with changes in polyamine levels and/or the activity of their metabolic enzymes. Faulty antizyme reg...

Hajime Sugiura and Susumu Hasegawa Department of Urology, Nagoya City University Medical School (Director: Prof. N. Oka) Since our original report of transrectal approach using television fluoloscopy for roentgenographic visualization of benign prostatic hyperplasia, we have continued to apply this technique to the cases of benign hyperplasia, carcinoma, inflammatory disease and normal conditio...

Our method of exfoliative cytology using a prostatic fluid collecting catheter is effective in detecting prostatic carcinoma. To presume histological diagnosis by means of the cytology we analyzed cytological findings of 62 cases of prostatic carcinoma in relation with their biopsy findings, clinical stages and clinical courses. In cases in which cellular atypism was low in the cytology the car...

ntroduction: Granulomatousprostatitis is an inflammatory condition of the prostate that histologically features the presence of granulomas. In general, granulomatousprostatitis accounts for fewer than 1% of benign inflammatory conditions of the prostate. The epidemiologic correlations depend in part on the etiology. Methods: The study was done on 94 specimens over a period of three years. Secti...