Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and gamma-aminobutyric acid subtype A receptor antagonist, is such an antagonist of NMDA receptors. In cultured rat hippocampal n...

ME T H Y L N P R O P Y L ETHER is an isomer of di-ethyl ether and possesses the formula CHs-O(CHI)J-CHJ. The physical properties of the two drugs are similar, and the vapour pressure curve of methyl-n-propyl ether is such that it may be used in the Oxford Vaporizer No. 1 without any alteration in the calibration of the instrument (see Figure). Methyl-n-propyl ether has a very unpleasant pungent...

Neutral cannabinoids with a pentyl side chain-for example, cannabidiol, tetrahydrocannabinol, and cannabinol-are generally accompanied by homologs with a propyl side chain, of which at least one has psychotropic activity. Samples of hashish and marihuana from Asia especially sometimes have abundant amounts of propyl cannabinoids, the quantities being of the same order as that of the accompanyin...

Background: Worldwide, breast cancer is the most common invasive in women.It comprises 22.9% of cancers women and 16% all female cancers. It accounts for 15% deaths worldwide.Objective: to study expression ER/PR on by immunocytochemistry fine needle aspiration smears. Material Methods: A prospective was carried out 120 cases lump, referred from various clinical Departments cytopathology lab a t...

Organophilic groups of coupling agents can be the key factor for electrical performance Boron Nitride (BN)/meta-aramid composite paper. In this article, four types triethoxy-silane with different organophilic groups, including mercapto-propyl (MP), glycidylether-propyl (GP), amino-propyl (AP) and trideca-fluoro-octyl (TFO) were studied. The structural properties modified papers compared, molecu...

The title compound, C12H18N4O6S (systematic name: 4-di-propyl-amino-3,5-di-nitro-benzene-sulfonamide), is a sulfonamide with herbicidal properties marketed as oryzalin. The dihedral angles between the benzene ring and the mean planes of the nitro groups are 26.15 (11) and 54.80 (9)°. The propyl arms of the di-propyl-amino substituent lie on opposite sides of this ring plane. In the crystal, N-H...

Acne vulgaris is a chronic and prevalent usually self-limited disorder. Topical medication is the main route for acne therapy. In this disorder the most widely used topical preparations are antibiotics such as Erythromycin and keratolytic agents such as Tretinoin. Excellent results with minimal side effects may be achieved by a fixed combination of Tretinoin and Erythromycin. This combination t...

As one of the oldest distillates in the world, flavor compounds of Chinese Baijiu (Chinese liquor) were extremely complex. Propyl lactate was firstly detected by direct injection and gas chromatography-mass spectrometry (GC-MS) in 72 Chinese Baijius. The objectives were to detect the contents of propyl lactate and evaluate its contribution to the aroma of Chinese Baijiu based on odor activity va...

Gametangia of the aquatic phycomycete Allomyces macrogynus have a cyanide- and antimycin A-insensitive respiration, which is sensitive to salicylhydroxamic acid (alternative respiration). Propyl gallate is also an inhibitor of this alternative pathway, and propyl gallate is more efficient than hydroxamic acid. Gametangial respiration is insensitive to propyl gallate, but propyl gallate sensitiv...