Proprotein convertase subtilisin/kexin type-9 (PCSK9) variants have been linked to hypercholesterolemia, atherosclerosis, and inflammation. Psoriasis is an inflammatory disease that associated with increased atherosclerotic risk. Here we demonstrate PCSK9 upregulated across multiple psoriasis RNA-Seq datasets its expression strongly correlates LDLR PLA2G3. Furthermore, identify a variant (rs662...

Heterozygous familial hypercholesterolemia (FH) is a genetic disorder characterized by high low-density lipoprotein cholesterol levels from birth, which exposes the arteries to high levels of atherogenic lipoproteins lifelong and results in a significantly increased risk of premature cardiovascular events. The diagnosis of FH, followed by an appropriate and early treatment is critical to reduce...