The increase in our knowledge of the immune mechanisms leading to the formation of the sarcoid granuloma unfortunately has not resolved the key question dealing with the etiologic agent(s) causing the disease. In this article, many genomes of Propionibacterium acnes or Propionibacterium granulosum were detected in specimens from 15 lymph node biopsies from 15 patients with sarcoidosis by using ...

Propionibacterium acnes belongs to the cutaneous flora of humans and is rarely considered a pathogen in human diseases. It is a frequent contaminant in blood cultures; however, in some patients it has been identified as the causative agent of life-threatening infections. Within the last years we have observed an abrupt increase in severe P. acnes infections which prompted us to study in detail ...

Two propionibacteria identified as Propionibacterium acnes and Propionibacterium granulosum were grown anaerobically in the presence of growth subinhibitory concentrations (0.25 and 0.5 minimal inhibitory concentrations) of clindamycin, erythromycin, lincomycin, and tetracycline. Viable counts and assays of extracellular lipase were performed on samples taken at 24-h intervals over a 96-h perio...

The skin surface varies topographically owing to regional differences in skin anatomy and, according to culture-based studies, these regions are known to support distinct sets of microorganisms [1]. Regions with higher temperature and humidity encourage growth of Gram-negative bacilli, coryneforms and Staphylococcus aureus, whereas areas with high density of sebaceous glands encourage growth of...

In this study the methods of Hungate were used to quantitate the anaerobic bacteria present in commercially available ground beef, cheddar cheese, and German hand cheese. Of 235 anaerobic roll-tube isolates from ground beef and German hand cheese, all were facultative anaerobes. Of 213 anaerobic roll-tube isolates from cheddar cheese, 91% were facultative anaerobes and 9% were obligate anaerobe...

BACKGROUND An effective treatment strategy for acne vulgaris is the reduction of Propionibacterium acnes in the skin. The Helicobacter pylori-derived synthetic antimicrobial peptide HPA3NT3 is a customized α-helical cationic peptide with antibacterial and anti-inflammatory activity. OBJECTIVES To examine the role of HPA3NT3 as a treatment against P. acnes-induced skin inflammation. METHODS ...

A 59-year-old male diabetic was admitted with an acute myocardial infarction and had recurrent. Propionibacterium acnes bacteremia. Fifteen months after the initial admission a splenectomy was required for removal of a large splenic abscess caused by P. acnes. Although this organism represents part of the normal skin flora, its presence of blood cultures requires serious evaluation since it may...

A 68-year-old man underwent uncomplicated sequential cataract extractions performed more than a year apart. He presented 6 months after the second surgery with persistent intraocular inflammation in both eyes. Cultures from both eyes grew Propionibacterium acnes and he responded well to treatment. Suspicion for delayed-onset post-operative endophthalmitis must remain high in uveitis cases that ...

Background: The ethanolic extract of Anredera cordifolia (AC) leaves has previously been investigated to have antibacterial activity against Propionibacterium acnes. An active compound propionibacterium acnes was flavonoid. Objective: This study aimed compare antimicrobial differences between nanoparticles and alone. Method: AC were extracted then formulated into using chitosan as the polymer s...

A case of endocarditis caused by Propionibacterium acnes associated with an aortic root abscess is presented. This supports the current opinion that aortic root abscesses are not necessarily associated with microorganisms of high virulence.