نتایج جستجو برای: proliferator
تعداد نتایج: 11640 فیلتر نتایج به سال:
We have tested a new ligand for peroxisome proliferator-activated receptor-g, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the classic rat model with nitrosomethylurea as carcinogen. Rats were first treated with a single dose of nitrosomethylurea (50 mg/kg body weight, i.p.). Starting 1 week later, they were fed GW7845, at either 60 or 30 mg/kg of diet, for 2 months. Th...
The abbreviations used are: PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element(s); AOX, straight chain fatty acyl-CoA oxidase; L-PBE, peroxisomal enoylCoA hydratase/3-hydroxyacyl-CoA dehydrogenase bifunctional protein; PTL, peroxisomal 3-ketoacylCoA thiolase; G-6-P, glucose-6-phosphatase; C/EBPα, CCAAT enhancer-binding protein α; SREBP1, sterol regu...
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor . The signaling co...
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