background: serum prolactin level has been used as an alternative determinant to help differentiate epileptic from non-epileptic seizures. we aimed to analyze the association between serum prolactin concentration and epileptic seizure versus febrile seizure as well as seizure duration, single versus multiple seizure attacks and time lapse between seizure onset and blood sampling.   methods: sev...

Background: Psoriasis vulgaris is a common chronic and inflammatory disease of skin that its etiology is not completely known. However, it seems that genetic and environmental factors play a role in this disease. In vitro studies show that prolactin as a neurohormone has an etiologic effect on psoriasis. This study aimed to compare serum prolactin levels in psoriatic patients with control group...

Background: Endometriosis is a chronic hormone-dependent inflammatory disease determined by the presence of foci endometrial tissue outside uterine cavity. Genetic factors occupy leading position in etiopathogenesis this disease. With endometriosis, there pronounced hormonal imbalance sex hormones both lesion and body sick woman as whole. The aim study:To study associations polymorphism hormone...

The tripeptide hypothalamic releasing factor, thyrotropin-releasing hormone (TRH), rapidly increases prolactin gene transcription 7- to 12-fold in the GH4 rat pituitary cell line. The maximal rates of transcription are achieved within minutes and begin to attenuate within 1 h following addition of TRH. This transcriptional response appears to account for the observed effects of TRH on the accum...

The pituitary hormone prolactin (PRL) is best known for its role in the regulation of lactation. Recent evidence furthermore indicates PRL is required for normal reproduction in rodents. Here, we report on the insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary PRL expression. Indeed, the transpo...

introduction: pheromones play a great role in the reproductive and social behavior of animals. the main sources of pheromones are urine and paracrine secretions. through the neuroendocrine system, prolactin is a safe parameter to measure and compare the effects of pheromones on the sexual, maternal and also lactating behavior. methods: female rats were divided into 19 groups (n=8). to measure t...

Prolactin added to the incubation medium of lactating mammary epithelial cells is transported from the basal to the apical region of cells through the Golgi region and concomitantly stimulates arachidonic acid release and protein milk secretion. We report that when PRL is added after disorganisation of the Golgi apparatus by brefeldin A treatment, prolactin signalling to expression of genes for...

HC11 mouse mammary cells cultured in the presence of insulin, cortisol and prolactin for 24 h accumulated beta-casein mRNA. When the specific inhibitor of protein kinase C, GF 109203 X, was added to the medium with the hormones, the accumulation of beta-casein mRNA was unaltered, although the protein kinase C activity was almost completely suppressed. This suggests that protein kinase C is not ...