The prevalence of small-pox at the present day in the parish of Marylebone is calculated to raise grave doubts in the minds of the public of the value of the discovery of the philanthropic Jenner ; or to impress them with the conviction that the Act for Compulsory Vaccination is shamefully ' neglected. To investigate the cause of this epidemic is no doubt one of the special objects of the Epide...

Cellular senescence is defined as permanent cell cycle arrest induced by various stresses. Although the p53 transcriptional activity is essential for senescence induction, the downstream genes that are crucial for senescence remain unsolved. Here, by using a developed experimental system in which cellular senescence or apoptosis is induced preferentially by altering concentration of etoposide, ...

Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophrenia. In the Prodh-null mouse, an interaction between elevated peripheral proline and another 22q11....

From the perspective of historiography, the article analyzes the construction of scientific medicine's major landmark: the small-pox vaccine. When this vaccine was created and widely distributed, the medical field demonstrated how technology controls life on a planetary scale. The great victory of scientific medicine rests on the fact that today the life of the small-pox virus depends upon labo...

Rahman, l.r.c p. and lf.p s. (Glas.), Civil Surgeon, Burma. This Manual 1ms been compiled by Dr. Rahman to explain the methods of vaccination and its superiority to the dangerous practice of inoculation against small-pox. We entirely agree with him that a systematic training is necessary in the method of vaccination. The first chapter deala with the mortality from small-pox, its infectivity, it...

Animal models have been useful in elucidating the genetic basis of the cognitive and behavioural phenotypes associated with the 22q11.2 microdeletions. Loss-of-function models have implicated a number of genes as playing a role in prepulse inhibition (PPI) of the startle response. Here, we report the generation and initial analysis of bacterial artificial chromosome (BAC) transgenic (Tg) mice, ...

In a series of experiment, the response of two contrasting potato species, namely,  Solanum acaule (tolerant) and Solanum tuberosum cv. Agria (intolerant) to salt (80 mM NaCl) and drought stress (15% polyethylene glycol;PEG) was studied in vitro. Furthermore, the role of acetyl salicylic acid (ASA) (1 and 10 µM) in alleviating oxidative stress was investigated. In Agria cultivar, NaCl and PEG r...

Three Hungarian (no. 2, 4 and 9), and a Moldavian (K) plum pox virus isolates were compared with a characterized Spanish isolate (5.15) by RT-PCR, ELISA, dot-blot and Western blot analysis. Monoclonal antibodies prepared against the external, intermediate and internal sequences of the coat protein of the Spanish isolate were able to differentiate the four isolates. Hungarian isolate No. 2 prove...

Aim. Production of genetically modified plants new promising winter wheat genotypes with partial suppression the proline dehydrogenase gene in vitro culture and determination content transgenic control plants. Methods. Agrobacterium-mediated transformation vitro, molecular genetic analysis; biochemical content; mathematical statistics. Results. Using method callus cultures wheat, carrying a dou...