Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority of natural products remain undiscovered, and computational methods to connect biosynthetic gene clusters to their corresponding natural products therefore have the potential to revitalize natural product discovery. Previously, we describ...

AIMS To use PRISM (Pictorial Representation of Illness and Self Measure), a visual instrument that has recently been developed and validated to assess suffering in patients with chronic physical illness, in orofacial pain patients and test for associations of PRISM with established assessment tools for pain, affective symptoms, and sleep. Of particular interest was the utility of PRISM as a scr...

We present the results of a simulation study of a multilayer structure for which strongly enhanced (resonant) electric fields are produced at the surface of, and in the interior of, a planar waveguide which is evanescently coupled to an incoming beam in a prism geometry. The resulting field enhancements can far exceed those associated with the well-known surface plasmon resonance in a typical s...

This paper examines the impact of Knightian uncertainty upon optimal climate policy through the prism of a continuous-time real option modelling framework. We analytically determine optimal intertemporal climate policies under ambiguous assessments of climate damages. Additionally, numerical simulations are provided to illustrate the properties of the model. The results indicate that increasing...

BACKGROUND To compare the performance of the Pediatric Risk of Mortality (PRISM), the Pediatric Index of Mortality 2 (PIM 2) and Pediatric Logistic Organ Dysfunction (PELOD) scores at general pediatric intensive care unit in a developing country setting, investigating the relation between observed and predicted mortality. METHOD A contemporary cohort study was undertaken at Pediatric Intensiv...

This paper presents a method for real-time rendering of a neocortical column in the mouse brain with 10000 individually simulated neurons, as implemented in the software GabrielStudio (TM). It also presents how the same system is used to create movie sequences of scripted camera keyframes for high resolution outputs. The current system is running on an SGI Altix Prism Extreme with 16 parallel g...

We present direct measurements of the absolute energy distribution of relativistic electrons generated in intense, femtosecond laser interaction with a solid. Cherenkov emission radiated by these electrons in a novel prism target is spectrally dispersed to obtain yield and energy distribution of electrons simultaneously. A crucial advance is the observation of high density electron current as p...

In this paper we demonstrate low loss transmission both above and below the primary band-gap for a photonic crystal (PC) super-prism device consisting of 600 lattice periods. By modifying the refractive index of the holes, we reduce overall insertion loss to just 4.5 dB across the entire visible spectrum. We show that the remaining loss is predominantly due to impedance mismatch at the boundari...

Prism has been developed as a modular classification rule generator following the separate and conquer approach since 1987 due to the replicated sub-tree problem occurring in Top-Down Induction of Decision Trees (TDIDT). A series of experiments have been done to compare the performance between Prism and TDIDT which proved that Prism may generally provide a similar level of accuracy as TDIDT but...