MOTIVATION The development of high-throughput sequencing technologies has enabled novel methods for detecting structural variants (SVs). Current methods are typically based on depth of coverage or pair-end mapping clusters. However, most of these only report an approximate location for each SV, rather than exact breakpoints. RESULTS We have developed pair-read informed split mapping (PRISM), ...

Methods: Forty-three participants with homonymous hemianopia were fitted with temporary press-on Fresnel peripheral prism segments of 40 prism diopters. Follow-up questionnaires evaluating functional benefits for mobility were administered in the office at week 6. Participants who continued wearing the prisms were interviewed again by telephone after a median of 12 months. Primary outcome measu...

Data and theory from prism adaptation are reviewed for the purpose of identifying control methods in applications of the procedure. Prism exposure evokes three kinds of adaptive or compensatory processes: postural adjustments (visual capture and muscle potentiation), strategic control (including recalibration of target position), and spatial realignment of various sensory-motor reference frames...

We conducted this study to evaluate the outcome of 203 patients admitted to PICU, using PRISM score. Overall mortality was 16.7%. The mean PRISM score was 6.5+/-3.6 and 15.5+/-7 for survivors and non survivors, respectively (OR: 1.36; 95% CI=1.24 -1.5; P<0.001). PRISM score also correlated well with length of hospital stay and the number of organ failures (P<0.001). A cut off score of 15 was as...

Prism adaptation may alleviate some symptoms of spatial neglect. However, the mechanism through which this technique works is still unclear. This study investigated whether prism adaptation differentially affects dysfunction in perceptual-attentional 'where' bias versus motor-intentional 'aiming' bias. Five neglect patients performed a line bisection task in which lines were viewed under both n...

OBJECTIVE To determine the functional utility for general mobility of peripheral prism glasses, a novel visual field expansion device for hemianopia, in a large-scale, community-based, multicenter study with long-term follow-up. METHODS Forty-three participants with homonymous hemianopia were fitted with temporary press-on Fresnel peripheral prism segments of 40 prism diopters. Follow-up ques...

PURPOSE We evaluate solutions for an applanating surface modification to the Goldmann tonometer prism, which substantially negates the errors due to patient variability in biomechanics. METHODS A modified Goldmann or correcting applanation tonometry surface (CATS) prism is presented which was optimized to minimize the intraocular pressure (IOP) error due to corneal thickness, stiffness, curva...

The integration of optical components into microfluidic systems has the potential to reduce the amount of bulky external devices and thus reduce the cost. However, one of the challenges of this concept is the accurate alignment of the optical path among multiple optical components inside a chip. We propose a tunable micro-optofluidic prism based on the liquid-core liquid-cladding structure form...

Adaptation of arm movements to laterally displacing prism glasses is usually highly specific to body part and movement type and is known to require the cerebellum. Here, we show that prism adaptation of walking trajectory generalizes to reaching (a different behavior involving a different body part) and that this adaptation requires the cerebellum. In experiment 1, healthy control subjects adap...

Recent evidence has implicated posterior parietal cortex (PPC) in adaptation to optical displacing prisms. It has been suggested that PPC contributes to the strategic component of prism adaptation necessary for perceptual realignment (true adaptation). It has also been suggested, however, that the part of PPC responsible for corrections to ongoing movements (a putative strategic component) may ...