نتایج جستجو برای: primary central nervous system lymphoma pcnsl
تعداد نتایج: 3162801 فیلتر نتایج به سال:
Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma with poor long-term survival. This study assessed methotrexate (MTX) plus idarubicin (IDA) in treating patients of PCNSL comparing to MTX alone therapy. A total of 100 patients were retrospectively enrolled and subjected to MTX alone (n = 52) and MTX plus IDA (n = 48). The completed response (CR) rate in pati...
Vitreoretinal lymphoma (VRL) is a rare variant of primary central nervous system (PCNSL), mostly diffuse large B cell lymphoma, which affects the retina and/or vitreous with or without optic nerve involvement. The disease course aggressive. Up to 90% patients develop within one year. diagnosis VRL challenging due nonspecific chronic and relapsing uveitis made by anterior chamber tab aspirate bi...
Primary central nervous system lymphoma (PCNSL) is a rare subtype of non-Hodgkin’s lymphoma in which disease is restricted to the craniospinal axis [1]. Ocular involvement can occur in 10-20% of cases and leptomeningeal disease is documented in 20-30%. PCNSL represents 2% of all lymphoma diagnoses (and 3% of all brain tumour presentations) and the incidence is reported in the range of 4 cases/m...
Despite recent therapeutic advances, primary central nervous system lymphoma (PCNSL) shows the worst prognosis among all non-Hodgkin lymphomas (NHLs), with a 5-year survival rate ranging from 4 to 40% [1,2]. Front-line therapy for patients with PCNSL is a combined chemo-radiotherapy regimen. High-dose chemotherapy with autologous stem cell support (ASCT) is still under investigation as consolid...
The brain microenvironment deeply differs from the of any other organ. is, in fact, characterized by distinct metabolic conditions and immune environment, it is composed unique cell types such as neurons cells glia, like astrocytes microglia. Increasing evidence suggests that plays an important role pathogenesis tumors metastases. However, how human niche interacts with eventually remodeled pri...
Mucosa-associated lymphoid tissue (MALT) lymphoma is one of the most common lymphomas and accounts for about 7% of all newly diagnosed non-Hodgkin's lymphoma (NHL). The clinical course of MALT lymphoma is relatively indolent and, in the majority of cases (50%), the lymphoma arises within the stomach. Primary central nervous system lymphoma (PCNSL), an uncommon variant of extranodal NHL, can aff...
Primary central nervous system lymphoma (PCNSL) is characterized as an extra-nodal non-Hodgkin lymphoma which develops from the neuraxis. The purpose was to report a case of a patient with a supra-tentorial tumor who underwent subtotal resection of his tumor as his biopsy was not indicative of a PCNSL tumor and had uneventful recovery until his last follow-up. A 42-year-old man was admitted to ...
Brain biopsy plays a crucial role in the exploration of suspect white matter lesions in the differential diagnosis of primary central nervous system lymphoma (PCNSL) and inflammatory demyelination. We present the case of a previously healthy, immunocompetent woman, aged fifty-nine, who developed a histologically confirmed demyelinating white matter lesion months prior to the manifestation of a ...
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patie...
A 77-year-old woman presented with worsening cognitive impairment, nausea and vomiting. Computed tomography (CT) of the head revealed a high-density mass that symmetrically filled both lateral ventricles. Magnetic resonance imaging (MRI) showed an enhanced mass with T1 and T2 prolongation and restricted diffusion on diffusion weighted imaging (DWI). Diagnosis was delayed until a post-mortem exa...
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