Osteosarcomatosis (also known as multifocal osteosarcoma or multiple sclerotic osteosarcoma) describes a condition in which there are multiple intraosseous foci of osteosarcoma at the time of presentation. Previous investigators have considered osteosarcomatosis to represent multicentric primary neoplasia. More recently it has been suggested that all cases of osteosarcomatosis represent rapidly...

Primary bone cancers are rare and affect fewer than 2500 people yearly in the United States. Osteosarcoma, the most common malignant primary bone tumor, has an annual incidence of 2 cases per million people. Advances in surgical and medical therapies have dramatically improved the prognosis of osteosarcoma during the last few decades. Early detection by primary care physicians remains a corners...

PURPOSE Pulmonary metastasis remains the major cause of mortality in osteosarcoma. Src tyrosine kinase is a key player involved in metastatic pathways in multiple human cancers. c-Src has been shown to be expressed and phosphorylated in osteosarcoma cell lines and inhibiting Src phosphorylation in these cells causes inhibition of the metastatic phenotype in vitro. We studied the effect of inhib...

Extraskeletal osteosarcoma is a rare soft tissue sarcoma and is in many ways distinct from skeletal osteosarcoma, including demographics, imaging feature, prognosis and management. We present a case of extraskeletal osteosarcoma arising from the retroperitoneum with dense ossification proved to be osteosarcoma by surgical resection. We describe the computed tomography (CT) and magnetic resonanc...

BACKGROUND The molecular mechanisms that are involved in the growth and invasiveness of osteosarcoma, an aggressive and invasive primary bone tumor, are not fully understood. The transcriptional co-factor FHL2 (four and a half LIM domains protein 2) acts as an oncoprotein or as a tumor suppressor depending on the tissue context. In this study, we investigated the role of FHL2 in tumorigenesis i...

Osteosarcoma is the most common type of primary bone cancer in children and young adults. The prognosis of osteosarcoma is very poor when it is diagnosed with metastasis. Lysosomal‑associated membrane protein 3 (LAMP3) is a tumor‑specific protein induced by hypoxia, which stimulates invasion and metastasis of various cancer cells via hypoxia‑inducible factor (HIF). A previous study from our gro...

Osteosarcoma is the most common primary bone cancer of children and is established during stages of rapid bone growth. The disease is a consequence of immature osteoblast differentiation, which gives way to a rapidly synthesized incompletely mineralized and disorganized bone matrix. The mechanism of osteosarcoma tumorogenesis is poorly understood, and few proteomic studies have been used to int...

BACKGROUND Osteosarcoma is the most frequent type of malignant bone tumor in children and adolescents and is associated with a high propensity for lung metastasis. Recent experiments have indicated that PLA2G16 contributes to osteosarcoma progression and metastasis in both mouse and human osteosarcoma cell lines. The aim of this study was to compare the expression of PLA2G16 in non-metastatic a...

Primary breast osteosarcoma is a rare malignancy, with mostly case reports in the literature. The appearance of breast osteosarcoma on digital breast tomosynthesis imaging has not yet been described. A 69-year-old woman presents for routine screening mammography and is found to have a calcified mass in her right breast. Pattern of calcification appeared "sunburst" on digital breast tomosynthesi...