نتایج جستجو برای: pri ring

تعداد نتایج: 126131  

Journal: :Acta poloniae pharmaceutica 2015
Marcin Frączek Dariusz Kuśmierz Beata Rostkowska-Nadolska Andrzej Kutner Małgorzata T Latocha

Besides well-known effect on bone and mineral metabolism vitamin D is involved in essential non-calcemic regulatory mechanisms, such as cellular proliferation, differentiation and apoptosis in various cell types. Major limitation for therapeutic use of calcitriol, a hormonally active form of vitamin D, is its calcemic and phosphatemic action. Recently, more selective vitamin D analogs which ret...

Journal: :Current Biology 2010
Liang Song Michael J. Axtell Nina V. Fedoroff

MicroRNAs (miRNAs) are excised from hairpin structures within primary miRNAs (pri-miRNAs). Most animal pri-miRNAs are processed by two cleavages, the first at a loop-distal site approximately 11 nucleotides (nt) from the end of the hairpin and the second approximately 22 nt beyond the first. To identify RNA structural determinants of miRNA processing in plants, we analyzed the functional conseq...

2015
Changhong Zhu Cheng Chen Jian Huang Hailong Zhang Xian Zhao Rong Deng Jinzhuo Dou Hui Jin Ran Chen Ming Xu Qin Chen Yanli Wang Jianxiu Yu

DGCR8 (DiGeorge syndrome critical region gene 8) is essential for primary microRNA (pri-miRNA) processing in the cell nucleus. It specifically combines with Drosha, a nuclear RNase III enzyme, to form the Microprocessor complex (MC) that cleaves pri-miRNA to precursor miRNA (pre-miRNA), which is further processed to mature miRNA by Dicer, a cytoplasmic RNase III enzyme. Increasing evidences sug...

Journal: :The Journal of Cell Biology 2008
Jan M. Pawlicki Joan A. Steitz

MicroRNAs (miRNAs) are noncoding RNAs with important roles in regulating gene expression. In studying the earliest nuclear steps of miRNA biogenesis, we observe that primary miRNA (pri-miRNA) transcripts retained at transcription sites due to the deletion of 3'-end processing signals are converted more efficiently into precursor miRNAs (pre-miRNAs) than pri-miRNAs that are cleaved, polyadenylat...

2008
Ian C. Paterson A. Keith Charnley Richard M. Cooper M. Clarkson

The insect pathogenic fungus Metarhizium anisopliae produces several extracellular cuticle-degrading proteases and evidence is consistent that one of these, a chymoelastase PRl, is a determinant of pathogenicity. We have shown previously that the wide-domain regulatory circuits of carbon and nitrogen derepression regulate PRI production. In the present work we have established in addition that ...

Journal: :Journal of cell science 2012
Clément Bellemer Marie-Line Bortolin-Cavaillé Ute Schmidt Stig Mølgaard Rask Jensen Jørgen Kjems Edouard Bertrand Jérôme Cavaillé

Nuclear primary microRNA (pri-miRNA) processing catalyzed by the DGCR8-Drosha (Microprocessor) complex is highly regulated. Little is known, however, about how microRNA biogenesis is spatially organized within the mammalian nucleus. Here, we image for the first time, in living cells and at the level of a single microRNA cluster, the intranuclear distribution of untagged, endogenously-expressed ...

Journal: :Molecular cell 2015
Wenwen Fang David P Bartel

MicroRNAs (miRNAs) are small regulatory RNAs processed from stem-loop regions of primary transcripts (pri-miRNAs), with the choice of stem loops for initial processing largely determining what becomes a miRNA. To identify sequence and structural features influencing this choice, we determined cleavage efficiencies of >50,000 variants of three human pri-miRNAs, focusing on the regions intractabl...

Journal: :Genome research 2015
Tsung-Cheng Chang Mihaela Pertea Sungyul Lee Steven L Salzberg Joshua T Mendell

Precise regulation of microRNA (miRNA) expression is critical for diverse physiologic and pathophysiologic processes. Nevertheless, elucidation of the mechanisms through which miRNA expression is regulated has been greatly hindered by the incomplete annotation of primary miRNA (pri-miRNA) transcripts. While a subset of miRNAs are hosted in protein-coding genes, the majority of pri-miRNAs are tr...

Journal: :Remote Sensing 2013
Yen-Ben Cheng Elizabeth M. Middleton Qingyuan Zhang Karl Fred Huemmrich Petya K. E. Campbell Lawrence A. Corp Bruce D. Cook William P. Kustas Craig S. T. Daughtry

The utilization of remotely sensed observations for light use efficiency (LUE) and tower-based gross primary production (GPP) estimates was studied in a USDA cornfield. Nadir hyperspectral reflectance measurements were acquired at canopy level during a collaborative field campaign conducted in four growing seasons. The Photochemical Reflectance Index (PRI) and solar induced chlorophyll fluoresc...

1996
Galen C. Hunt Michael L. Scott

We present a new algorithm for concurrent access to array-based priority queue heaps. Deletions proceed top-down as they do in a previous algorithm due to Rao and Kumar 6], but insertions proceed bottom-up, and consecutive insertions use a bit-reversal technique to scatter accesses across the fringe of the tree, to reduce contention. Because insertions do not have to traverse the entire height ...

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