Neste artigo mostramos um procedimento desenvolvido em nossos laboratórios que identifica “novos” compostos biologicamente ativos distintos de compostos previamente conhecidos no que diz respeito à especificidade da ação e outras características. O procedimento envolve o mapeamento de uma série de compostos ativos (série de treinamento), através de interações lipofílicas e de ligações hidrogêni...

ly, let M be the number of copies of a single multicast that a member receives from the lower dissemination layer. For the Pbcast implementation, since each member gossips a given multicast for O(log(n)) gossip rounds and to randomly chosen targets, we have M = O(log(n)). To maximize the throughput, one would want to minimize the number of copies M of a multicast that a member receives from the...

In underground excavation, where the road-headers are employed, a precise prediction of the road-header performance has a vital role in the economy of the project. In this paper, a new model is developed for prediction of the road-header performance using the non-linear multivariate regression analysis. This model is able to estimate the instantaneous cutting rate (ICR) of roadheader based on r...

nary tuberculosis were treated with ethionamide I gm. daily (in the form of uncoated tablets) and isoniazid 400 mg. daily. Patients with gross cavitation and extensive disease were excluded. Examination of urine for albumin, blood and bile was carried out weekly; liver function tests (serum albumin, and globulin, serum billrubin, thymol turbidity, alkaline phosphatase) monthly; chest x-ray film...

Instant messaging and presence-systems have long been popular in the “fixed” Internet world with tens of millions of PC users. The success has come despite the heterogeneous environment of multiple incompatible IM systems. In the mobile domain, however, instant messaging and presence is a relatively young thing. Hoping to avoid fragmentation in mobile IM and presence, Wireless Village was forme...

Studies using anesthesia provide insights into oral phantoms. The chorda tympani nerve is accessible for anesthesia at two sites. First, the chorda tympani leaves the tongue with the lingual nerve (CN V) and the two travel through the pterygomandibular space. The inferior alveolar nerve, which conveys pain from the lower teeth, passes through the same space; thus dental anesthesia abolishes tas...

Background: To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution. Results: Here we describe a suite of methods that provide the first quantitative three-dimensional description of gene expression and morphology at cellular resolution in whole embryos....