Presbycusis is the most common sensory impairment associated with aging; however, the underlying molecular mechanism remains unclear. Autophagy has been demonstrated to serve a key role in diverse diseases; however, no studies have examined its function in central presbycusis. The aim of the present study was to investigate the changes of autophagy in the physiological processes of the auditory...

In order to provide a control population for a previous investigation of noise-induced hearing loss in a population of female jute weavers (Taylor, Pearson, Mair, and Burns, I965) a survey was conducted on the hearing thresholds of 296 school teachers in Dundee, Scotland, by pure tone earphone listening. This population, although not exposed to industrial noise, is subjected to city noise and d...

Elevated total serum homocysteine (tHcy) concentrations associated with vitamin B-12 or folate deficiencies may adversely affect blood flow to the cochlea, leading to age-related hearing loss (presbycusis). However, only 2 small cross-sectional studies have assessed the link between folate, vitamin B-12, or tHcy and presbycusis. We aimed to determine both the cross-sectional and longitudinal as...

OBJECTIVES Morphological studies on presbycusis, or age-related hearing loss, have been performed in several different strains of mice that demonstrate hearing loss with auditory pathology. The C57BL/6 (C57) mouse is a known model of early onset presbycusis, while the CBA mouse is characterized by relatively late onset hearing loss. We performed this study to further understand how early onset ...

Age-related hearing loss (presbycusis) is thought to result from age-related degeneration (aging) of the cochlea plus the cumulative effects of extrinsic damage (noise and other ototoxic agents) and intrinsic disorders (e.g. systemic diseases). Previous studies have implicated dysfunction of the hair cells (sensory presbycusis) as the principal mechanism of age-related hearing loss. However, re...

Presbycusis and noise-induced hearing loss result in characteristic audiogram curves with increasing levels of at higher frequencies. Another specific form curve is the cookie bite, which often inherited sometimes illness or injury. The influence on speech intelligibility was examined along a list words selected according to frequency range phonemes present. Dependence dominant loss, lower, mid...

Age-related dysfunction of the central auditory system, known as central presbycusis, is characterized by defects in speech perception and sound localization. It is important to determine the pathogenesis of central presbycusis in order to explore a feasible and effective intervention method. Recent work has provided fascinating insight into the beneficial function of H2S on oxidative stress an...

Shanghai Institute of Geriatrics and Gerontology, Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai, China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Otolaryngology, Huadong Hospital, Shanghai Medical College, Fudan University, ...