Rady, M.I.* and Amany M. Osman** J. Egypt. Soc. Toxicol. (Vol. 35: 19-25 July 2006) WWW.estoxicology.org * Department of Zoology, Faculty of Science, Al Azhar University and ** Department of Zoology, Girls College for Art, Science & Education, Ain Shams University ABSTRACT This study dealt with the evaluation of the histological alteration due to feeding on fried bread and the protective role...

Life does not start at birth but conception. Embryonic development is a particularly difficult period in which genetic and environmental factors can interact to contribute risk. In utero early neonatal exposure maternal stress are linked with psychiatric disorders, the underlying mechanisms currently being elucidated. This study examined novel relationships between noise causing oxidative-stres...

BACKGROUND Prenatal exposure to Lipopolysaccharide (LPS) produces hypertension in adult offspring rats. The present study was to explore the effects of prenatal inflammation on morphological and functional changes in the aorta from offspring rats and to further assess its susceptibility to cardiovascular diseases. METHODS AND RESULTS Pregnant rats were treated intraperitoneally on gestation D...

It has been known that methadone maintenance treatment is the standard treatment of choice for pregnant opiate addicts. However, there are few data on newborn outcomes especially in the cross talk with other addictive agents. The present study was to investigate the effect of prenatal exposure to methadone on methamphetamine (METH)-induced behavioral sensitization as an indicator of drug addict...

Ketamine is commonly used for anesthesia and as a recreational drug. In pregnant users, a potential neurotoxicity in offspring has been noted. Our previous work demonstrated that ketamine exposure of pregnant rats induces affective disorders and cognitive impairments in offspring. As the prefrontal cortex (PFC) is critically involved in emotional and cognitive processes, here we studied whether...

The offspring of rats with experimental hyperhomocysteinemia caused by alimentary loading with dietary methionine within pregnancy has been studied. Using pinealon (Glu-Asp-Arg) under these conditions was found to result in the offspring cognitive function being improved significantly and their cerebellum neurons becoming more resistant to oxidative stress. This may be proved by the fact that t...

In this study, we attempted to design a model using Sprague-Dawley rats to better reproduce perinatal systemic hypoxic-ischemic encephalopathy (HIE) in early preterm newborns. On day 21 of gestation, the uterus of pregnant rats were exposed and the blood supply to the fetuses of neonatal HIE groups were thoroughly abscised by hemostatic clamp for 5, 10 or 15 min. Thereafter, fetuses were moved ...

introduction: gestational stress can lead to cerebral functional disorders, such as epilepsy, probably due to the disturbance in the cerebral maturation and causing abnormal neuronal correlations. in the present study, effect of gestational predator stress on the neonatal epileptic behaviors was investigated in rats. methods: female rats (200 ± 20 g) were divided into two groups intact pregnant...

Feeding pregnant rats a protein-restricted (PR) diet induces altered expression of candidate genes in the liver of the adult offspring, which can be prevented by supplementation of the PR diet with folic acid (PRF). We investigated the effect of maternal nutrition during pregnancy on the liver transcriptome in their adult male offspring. Pregnant rats were fed control, PR or PRF diets. Male off...