High dimensional data is the situation in which the number of variables included in an analysis approaches or exceeds the sample size. In the context of group classification, researchers are typically interested in finding a model that can be used to correctly place an individual into their appropriate group; e.g. correctly diagnose individuals with depression. However, when the size of the tra...

The gut microbiota is commonly referred to as a hidden organ due to its pivotal effects on host physiology, metabolism, nutrition and immunity. The gut microbes may be shaped by environmental and host genetic factors, and previous studies have focused on the roles of protein-coding genes. Here we show a link between long non-coding RNA (lncRNA) expression and gut microbes. By repurposing exon m...

Inherited genetic variation plays a critical but largely uncharacterized role in human differentiation. The completion of the International HapMap Project makes it possible to identify loci that may cause human differentiation. We have devised an approach to find such ethnically variant single-nucleotide polymorphisms (ESNPs) from the genotype profile of the populations included in the Internat...

MOTIVATION Classification of biological samples by microarrays is a topic of much interest. A number of methods have been proposed and successfully applied to this problem. It has recently been shown that classification by nearest centroids provides an accurate predictor that may outperform much more complicated methods. The 'Prediction Analysis of Microarrays' (PAM) approach is one such exampl...

OBJECTIVES To identify and compare the gene expression profiles of actinic keratosis (AK) and squamous cell carcinoma (SCC) and to further clarify critical genetic alterations in the evolution of SCC from normal sun-damaged human skin. DESIGN Observational study. SETTING University practice. PATIENTS Skin biopsy specimens were obtained from 16 patients. The specimens included 14 normal no...

The present study was aimed to study the effects of hyperlipidaemia on the histology of various reproductive organs. The chronic oral administration of cholesterol diet (400 mg/kg bodyweight/day for 60 day) induced hyperlipidaemia in male rabbits. It showed severe degeneration in germinal epithelium. Few spermatocytes could be seen, but the number was decreased. The seminiferous tubules were wa...

We assessed the dermatological manifestations associated with chronic hepatitis C virus (HCV) infection and their association with liver status. Of 155 patients with chronic HCV infection in Cairo, Egypt, 71 (45.8%) had dermatological manifestations: pruritus without evident skin lesions (21.3%), pigmented purpuric eruption (5.2%), aphthous ulcer and lichen planus (3.9% each), leukocytoclastic ...