Long-term potentiation is a long-lasting, use-dependent increase in the strength of synaptic connections. We investigated the role of nitric oxide (NO) in determining the duration of potentiation induced by high frequency stimulation of afferents in the CA1 region of the rat hippocampus. The calcium/calmodulin-dependent production of NO can be initiated by activation of excitatory amino acid re...

1. Pairing low-frequency orthodromic stimulation with high-frequency antidromic conditioning of pyramidal cells in area CA1 of the rat hippocampus resulted in long-lasting potentiation of the extracellular population spike of the cells, without an accompanying increase in the extracellular excitatory postsynaptic potential (EPSP), indicating an increase in EPSP-spike (E-S) coupling, also called...

Introduction: Over the last decade, exposure to non-ionizing electromagnetic waves due to base station antenna has increased. This in vivo study was planned for evaluating the effects of whole-body exposure to 950 MHz field of GSM mobile phone system on rat dentate gyrus long-term potentiation. Materials and Methods: 24 naive male Wistar rats (3 month old, 225|¡|25 g) were randomly divided in t...

An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation in the hippocampus of rats. Intraperitoneal injections of the drug markedly increased the degree and duration of long-term potentiation; similar results were obtained with an ana...

Long-term potentiation (LTP) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. The first clue of the potential role of glutamate receptors in LTP was in 1991 with the observation that the mGluR agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (ACPD), increased LTP. Studies have shown that ACPD induc...

Introduction: Intravenous general anesthetic agents are among the most important and widely used anesthetic drugs in the clinical practice. Many pharmacological studies have shown that potentiation of GABA and glycine on their receptors is the most plausible mechanism. Nevertheless, there is limited information on the effects of co-administration of two or more of these agents. However, expe...

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...

The purpose of this study was to examine the relationships between muscle cross-sectional area (CSA), maximal strength, power output, and maximum potentiation characteristics. The vastus lateralis and biceps femoris CSA, one repetition maximum (1RM) back squat, 1RM concentric-only half-squat (COHS) strength, static jump power output, and maximum potentiation characteristics of 17 resistance-tra...

Long-term increases in the strength of excitatory transmission at Schaffer collateral-CA1 cell synapses of the hippocampus require the insertion of new alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) into the synapse, but the kinetics of this process are not well established. Using microphotolysis of caged glutamate to activate receptors at single dendritic spines in hip...