The etiology of common idiopathic epileptic syndromes is genetically determined, but the complex pattern of inheritance suggests an epistatic interaction of several susceptibility genes. Mutations in over 70 genes now define biological pathways leading to rare monogenic forms of epilepsy in humans and animals. Recognizing the molecular basis of an ion-channel disease has provided new opportunit...

The etiology of common idiopathic epileptic syndromes is genetically determined, but the complex pattern of inheritance suggests an epistatic interaction of several susceptibility genes. Mutations in over 70 genes now define biological pathways leading to rare monogenic forms of epilepsy in humans and animals. Recognizing the molecular basis of an ion-channel disease has provided new opportunit...

Potassium is an earth abundant alternative to lithium for rechargeable batteries, but a critical limitation in potassium ion battery anodes is the low capacity of KC8 graphite intercalation compounds in comparison to conventional LiC6. Here we demonstrate that nitrogen doping of few-layered graphene can increase the storage capacity of potassium from a theoretical maximum of 278 mAh/g in graphi...

Potassium ion channels are transmembrane proteins that selectively facilitate ion flow down an electrochemical gradient between intracellular and extracellular environments. There is accumulating evidence which suggest that potassium channel protein activity is important in the pathophysiology of cancer, and associations of the two-pore domain family of potassium channels and breast cancer are ...

Motility of Bacillus subtilis was inhibited within a few minutes by a combination of valinomycin and a high concentration of potassium ions in the medium at neutral pH. Motility was restored by lowering the concentration of valinomycin or potassium ions. The valinomycin concentration necessary for motility inhibition was determined at various concentrations of potassium ions and various pH's. A...

Polymer-supported liquid-crystal membranes have been designed for neutral-carrier-type potassium ion-selective electrodes, aiming for practical applications of high-performance liquid-crystalline membrane ion sensors. Two types of polymer-supported liquid-crystal membranes were tested for their usefulness; one is microporous poly(tetra fluoroethylene) (PTFE) membranes impregnated by thermotropi...

background: potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. high serum potassium levels are thought to impair pulse conduction in purkinje fibers and ventricles more than that in the atrioventricular (av) ...