BACKGROUND Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia. AIMS To evaluate, in a large multicentre trial, the use of the kappa receptor agonist fedotozine to improve symptoms associated with functional dyspepsia. METHODS Two or more of the following persistent symptoms were required for inclusion: epigastric pain, early s...

Indeed if there is a criticism of the new edition with its expanded information base, it is that it is becoming more readable and is in some danger of turning into a textbook. It is clearly acknowledged in the introduction that many of the protocols described should not be considered unique or exclusive. This point is reiterated on occasions in the text where specific therapies are noted to be ...

A fifty four years old male was followed in nephrology clinic since 1999 for hepatorenal polycystic disease. The patient was referred for abdominal distension with postprandial fullness. Family history of hepatorenal polycystic disease in the father, grandmother and a paternal aunt. On physical examination there was a globular abdomen, with multiple irregular masses, which imprint on the abdomi...

Superior mesenteric artery (SMA) syndrome is an uncommon cause of proximal intestinal obstruction, frequently occurring in patients who have had an important weight loss. The diagnosis can be difficult and usually is made by exclusion. The most characteristic symptoms are postprandial epigastric pain, fullness, voluminous vomiting and eructation. These symptoms are due to the compression of the...

Dyspepsia is a complex condition comprising chronic and recurrent symptoms related to the upper gastrointestinal tract. The cardinal symptoms are epigastric pain and discomfort, including postprandial fullness and early satiety, which may overlap with heartburn and regurgitation. Box 1 shows the various definitions of dyspepsia. Around 25-40% of adults in the general population have dyspepsia, ...

The main factors involved in the pathophysiology of fat induced dyspepsia were investigated by reviewing a series of controlled double blind randomised studies which sought to determine the role of nutrient fat and the postprandial release of cholecystokinin (CCK) in the development of dyspeptic symptoms in healthy volunteers and in patients with functional dyspepsia. The studies showed that du...

Delayed gastric emptying in the absence of mechanical obstruction is referred to as gastroparesis. Symptoms that are often attributed to gastroparesis include postprandial fullness, nausea, and vomiting. Although tests of gastric motor function may aid diagnostic labeling, their contribution to determining the treatment approach is often limited. Although clinical suspicion of gastroparesis war...

Among functional gastrointestinal (GI) disorders, functional dyspepsia (FD) and irritable bowel syndrome (IBS) are important to public health around the world and are frequently encountered in general practice. Upper GI symptoms such as heartburn, postprandial fullness, early satiety, epigastric pain or burning and lower GI symptoms such as constipation and diarrhea often coexist. Although the ...

Achalasia cardia is a motility disorder, involving the distal esophagus, resulting in elevated lower esophageal sphincter pressure, increased intraesophageal pressure, incomplete relaxation of lower esophageal sphincter in response to deglutition and loss of esophageal peristalsis. It usually presents between third and fifth decades of life with the most common symptom of dysphagia. We present ...