BACKGROUND AND PURPOSE Identification of risk factors for dementia after stroke is best performed in comparison with stroke-free controls, because older subjects at high risk for stroke also have a substantial risk of dementia in the absence of stroke. Previous case-control studies were hospital-based. We used a nested case-control design to prospectively evaluate these risk factors in the comm...

Although Alzheimer’s disease (AD) characterized by progressive deterioration in cognitive function was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g. blood plasma, saliva and urine). Stroke patients often suffer from post-stroke cognitive impairment, or even from post-stroke dementia (PSD) [1]. Recently, excess form...

We determined the prevalence of dementia in 927 patients with acute ischemic stroke aged years in the Stroke Data Bank cohort based on the examining neurologist's best judgment Diagnostic agreement among examiners was 68% ( K = 0 3 4 ) . Of 726 testable patients, 116 (16%) were demented. Prevalence of dementia was related to age but not to sex, race, handedness, educational level, or employment...

thalamic pain syndrome, a type of central post-stroke pain (cpsp), may develops after a hemorrhagic or ischemic stroke and results in impairment of the thalamus. there is limited experience about gabapentin in treatment of central pains like cpsp.in a prospective observational study, the intensity of pain was recorded using the numeric rating scale (nrs) at the entrance to the study. patients e...

CONTEXT Next to Alzheimer disease, vascular dementia is the second most common form of dementia in the elderly, yet few specific risk factors have been identified. OBJECTIVE To investigate the relationship of plasma lipids and lipoproteins to dementia with stroke. DESIGN AND SETTING Prospective longitudinal community-based study over a 7-year period (1991-1998). PARTICIPANTS A total of 11...

BACKGROUND AND PURPOSE Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D,...

OBJECTIVE We studied a large hospitalized cohort of patients aged 55 years and over with acute ischemic stroke to identify the frequency and predictors of poststroke dementia. METHODS A total of 434 consecutive patients with ischemic stroke were enrolled in this study. During admission, the demographic data, vascular risk factors, stroke features, and neurological status information were coll...

BACKGROUND AND PURPOSE Frequency of poststroke dementia is high, and stroke considerably increases the risk of dementia. The risk factors for dementia related to stroke are still incompletely understood. We sought to examine clinical determinants of poststroke dementia in a large well-defined stroke cohort. METHODS The study group comprised 337 of 486 consecutive patients aged 55 to 85 years ...

Vascular dementia accounts for approximately 15-20% of all dementias. In addition, a significant subset of people with Alzheimer's disease have concurrent cerebrovascular disease. Vascular dementia is caused by different cerebrovascular morphological abnormalities including large artery territory infarction (multi-infarct vascular dementia) and sub-cortical ischaemic vascular dementia. Despite ...

Vascular dementia (VaD) comprises a group of syndromes caused by vascular lesions in the brain. Cognitive impairment may follow a single cortical or lacunar infarct in a strategic area of the brain, multiple infarcts, small-vessel disease (leukoaraiosis), intracerebral hemorrhage, or any of these conditions coexisting with Alzheimer dementia (so-called mixed dementia). Depending on case mix and...