The I1 subtype of imidazoline receptors (I1R) is a plasma membrane protein that is involved in diverse physiological functions. Available radioligands used so far to characterize the I1R were able to bind with similar affinities to 2-adrenergic receptors ( 2-ARs) and to I1R. This feature was a major drawback for an adequate characterization of this receptor subtype. New imidazoline analogs were...

BACKGROUND AND PURPOSE Improving actionable stroke knowledge of a witness or bystander, which in some cases are children, may improve response to an acute stroke event. METHODS We used a quasiexperimental pre-test post-test design to evaluate actionable stroke knowledge of 210 children aged 9 to 10 years in response to a single, 15-minute exposure to a stroke education video game conducted in...

Let A be a Tychonoff space. As is well known, the points of the Stone-Cech compactification ßX "are" the zero-set ultrafilters of X, and the points of the Hewitt real-compactification vX are the zero-set ultrafilters which are closed under countable intersection. It is shown here that a zeroset ultrafilter is a point of the Dieudonné topological completion SX iff the family of complementary coz...