BACKGROUND Some psychotropic drugs are connected with prolongation of QT interval, increased risk of cardiac arrhythmias and greater incidence of sudden death, especially when used in combination. Concomitant use of antipsychotics and antidepressants is not rare in our clinical practice. The study compares the length of QT interval in patients on monotherapy with an antipsychotic or an antidepr...

Commentary Although sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death among patients with epilepsy (1), risk factors identifying those most at risk have not been clarified. Currently, epilepsy and seizure severity factors including generalized tonic seizures (GTCS) are most commonly associated with SUDEP (1–4). In addition, studies suggest that antiepilepti...

Objective: This study aimed to investigate the relationship between acute-phase reactants and oxidative stress epilepsy. Methods: The patient group consisted of 67 patients who applied Pediatric Neurology outpatient clinic were diagnosed with generalized type epilepsy according ILAE classification, 33 receiving monotherapy 34 antiepileptic medication in form polytherapy. control included 30 hea...

OBJECTIVES To measure the adherence to polytherapy after myocardial infarction (MI), to compare the proportions of variation attributable to hospitals of discharge and to primary care providers, and to identify determinants of adherence to medications. SETTING This is a population-based study. Data were obtained from the Information Systems of the Lazio Region, Italy (5 million inhabitants). ...

OBJECTIVES Levetiracetam is a broad-spectrum antiepileptic drug (AED) which is currently licensed in the United States and the United Kingdom and Ireland for use as adjunctive treatment of focal-onset seizures and myoclonic seizures or generalized tonic-clonic seizures, occurring as part of generalized epilepsy syndromes. In the United Kingdom and Ireland, it is also licensed as monotherapy tre...

PURPOSE Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPSC) have been shown to survive transplantation and influence the recovery proc...