background:diabetic retinopathy (dr) is a sight-threatening microvascular complication of diabetes in which the vascular endothelium is damaged due to oxidative stress and inflammation, and vitreous vegf concentration becomes elevated. the aim of the present study was to assess the association of dr with genetic variations of the mnsod, a major antioxidant enzyme, and vegf, an important mediato...

background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who h...

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxida...

introduction reelin gene (reln) codes a large extracellular matrix glycoprotein with serine protease activity and is implicated in the modulation of neuronal signaling, synaptic transmission and plasticity. the reelin plays a fundamental and pivotal role in the development of laminar structures and may be one of the loci contributing to the positive linkage between chromosome 7q and autistic di...

the present  study  was carried out to investigate the polymorphism of intron 3 to exon 3 of prolactin gene containing 24 bpindel at nucleotide position (np)  358 and its association with some reproductive traits in japanese quail. these traits consisted of weight (wsm) and age at sexual maturity (asm), mean egg weight at 2nd, 4th, 6th, and 2-6th weeks (mew), and the number of eggs during the 2...

objective: jaundice with indirect hyperbilirubinemia is one of the most common neonatal problems that occur in 60% of term and 80% of preterm neonates but the causes are mostly unknown. it is suggested that race plays an important role in the prevalence of hyperbilirubinemia. it is a common problem in iran that worries both parents and pediatricians. it has been found that a mutation in the ugt...

AIMS The present study explored whether specific single-nucleotide polymorphisms in alcohol metabolic pathway are associated with alcohol dependence or alcohol-related psychopathological symptoms. METHODS Three groups of male unrelated subjects were included: 101 currently alcohol-dependent patients, 100 formerly alcohol-dependent subjects and 97 healthy controls. The following questionnaires...

Oxidative stress is significant in numerous types of disease including cancer. To protect cells and organs against reactive oxygen species (ROS), the body has evolved an antioxidant protection system that involved in the detoxification of ROS. Single nucleotide polymorphisms (SNP) of anti-oxidative enzymes may dramatically change the activity of the encoded proteins; therefore, certain alleles ...

Vitiligo is brought on by functional melanocyte loss and manifests as white maculae that may cover the whole body's skin. There a genetic background in pathogenesis of vitiligo. Polymorphisms different parts catalase gene affect disease activity result less catalase, thus, accumulation hydrogen peroxide, one oxidative factors damage melanocytes. We evaluated CAT 262 polymorphism vitiligo patien...

introduction: a thyroid nodule is a palpable swelling in a thyroid gland with an otherwise normal appearance. palpable thyroid nodules occur in 4 to 7 percent of the population. nodular thyroid diseases are more frequent in women than in men. most actions of thyroid hormone are mediated by the active form of thyroid hormone. d2 is essential for formation of active hormone of t3 through deiodina...