نتایج جستجو برای: polymerization of tubulin
تعداد نتایج: 21168029 فیلتر نتایج به سال:
To analyze the mechanism of Tat-mediated HIV pathogenicity, we produced a Drosophila melanogaster strain transgenic for HIV-tat gene and induced the expression of the protein during Drosophila development. By in vitro and in vivo experiments, we demonstrated that Tat specifically binds to tubulin via the MAP-binding domain of tubulin, and that this interaction delays the polymerization of tubul...
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key protein for bacterial cell division and a structural homologue of eukaryotic tubulin. Both tubulin and FtsZ contain a GTPbinding domain, have GTPase activity, assemble into protofilaments...
In Alzheimer's disease, hyperphosphorylated tau is an integral part of the neurofibrillary tangles that form within neuronal cell bodies and fails to promote microtubule assembly. Dysregulation of the brain-specific tau protein kinase II is reported to play an important role in the pathogenesis of Alzheimer's disease (Patrick, G. N., Zukerberg, L., Nikolic, M., De La Monte, S., Dikkes, P., and ...
Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. The major fermentation product, disorazole A(1), was found previously to irreversibly bind to tubulin and to have potent cytotoxic activity against tumor cells, possibly because of its highly electrophilic epoxide moiety. To test this hypothesis, we synthes...
Aggregation of the high-affinity IgE receptors (FcepsilonRIs) on the surface of granulated mast cells initiates a chain of signaling events culminating in the release of allergy mediators. Although microtubules are involved in mast cell degranulation, the molecular mechanism that controls microtubule rearrangement after FcepsilonRI triggering is poorly understood. In this study, we show that th...
What is it? γ-Tubulin is a member of the tubulin superfamily and is required for nucleating the polymerization of microtubules in vivo. Microtubules are dynamic cytoskeletal polymers that assemble from two other members of the tubulin superfamily, α-tubulin and βtubulin. Microtubules make up the mitotic and meiotic spindles, and are important for establishing cell polarity and vesicle trafficki...
Purified tubulin or microtubules are widely used for in vitro assays related to their function, such as activities of modifying enzymes and motor protein activity. This paper gave a review purification (MTs) using two different methods. One method MTs depended on polymerization depolymerization. were polymerized at 37 °C with taxol the presence. Another is purify by affinity column chromatograp...
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