A series of novel functional carbazole (Cbz)-based carboxylated monomers were synthesized and characterized. A Clauson-Kaas procedure, a deprotection step, amide coupling, and hydrolysis were utilized as key chemical reactions towards the multistep synthesis of monomers in good to excellent isolated yields. The design strategy was further extended to complex carbazole-COOH monomers incorporated...

The objective of this study was to prepare diclofenac sodium loaded microparticles using the single emulsion [oil-in-water (o/w)] solvent evaporation method. The 2 2 experimental design methodology was using the Design-Expert ® software used to evaluate the effect of two formulation variables on the properties of the microspheres in terms of particle size, morphology, encapsulation efficiency, ...

OBJECTIVES Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of prepared microparticles and investigated the underlying mechanisms responsible for the 'burst release' effect. METHODS Using two different pH-responsive polymers wit...

We report the synthesis and self-assembly of amphiphilic, nonspherical, polymeric microparticles. Wedge-shaped particles bearing segregated hydrophilic and hydrophobic sections were synthesized in a microfludic channel by polymerizing across laminar coflowing streams of hydrophilic and hydrophobic polymers using continuous flow lithography (CFL). Particle monodispersity was characterized by mea...

Polymeric core–shell microparticles with hollow interiors have great potential for use as microencapsulation systems for controlled load/release, active protection, and confined microreaction. Core–shell structures with solid shells provide effective encapsulation; however, transport of the encapsulated molecule through the shell is more difficult. Addition of holes to the shell can provide mor...

BACKGROUND AND AIMS Recent studies have shown that low molecular weight heparins are effective in the treatment of inflammatory bowel disease. Therefore, there is considerable interest in the development of an oral colonic delivery pharmaceutical system allowing targeted release of heparin in the inflamed tissue. The objective of this study was to prepare microparticles for the oral administrat...

The controlled synthesis of micrometer-sized polymeric particles bearing features such as nonspherical shapes and spatially segregated chemical properties is becoming increasingly important. Such particles can enable fundamental studies on self-assembly and suspension rheology, as well as be used in applications ranging from medical diagnostics to photonic devices. Microfluidics has recently em...

Layer-by-layer (LbL) [1] assembly is a powerful tool for engineering microparticulate structures. On the one hand it allows one to tailor the surface chemistry of microparticles, rendering them responsive to physicochemical stimuli such as pH, ionic strength, light, and so on, to allow bio-specific recognition or just to prevent adsorption of unwanted species [2]. On the other hand, using micro...

The study reports on the development of a novel hepatitis b vaccine prepared by physically mixing smaller microparticles (8-12 μm; blend PCL-PLGA; containing equivalent to 10μg HBsAg) with larger microparticles (12-20 μm; blend PCL-PLA; entrapping 10μg HBsAg). The vaccine was reconstituted with alum adsorbed HBsAg (equivalent to 10μg HBsAg) and was injected in BALB/c mice subcutaneously as sing...