Polymeric micelles supply an environment, which can be cautiously regulated for drug delivery. The self-assembly of polymeric micellization is dynamic. Micellization thermodynamic describes how the system defines formation micelles. present study enables behavior surfactants in presence polymer to examined by conductometric and tensiometric methods. effects concentration temperature on thermody...

Polymeric micelles are supramolecular, core-shell nanoparticles that offer considerable advantages for cancer diagnosis and therapy. Their relatively small size (10-100 nm), ability to solubilize hydrophobic drugs as well as imaging agents, and improved pharmacokinetics provide a useful bioengineering platform for cancer applications. Several polymeric micelle formulations are currently undergo...

The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects owing to increased patient compliance. Unfortunately, the oral delivery route is beset with problems such as gastrointestinal (GI) destruction of labile molecules, low levels of macromolecular absorption, etc. To reduce the impact of digestive enzymes and to ensure the absorption of bioactive agents in...

water soluble chitosan oligosaccharide (cho) was hydrophobically modified with camptothecin (cpt) in different molar ratios of cpt, and characterized by ft-ir and 1 h-nmr spectroscopy. nanomicelles prepared by these copolymers were analyzed for size, zeta, and length of time they remain stable. the critical micelle concentration (cmc) and dissociation of micelles at physiological ph and acidic ...

Nano-sized polymeric amphiphilic micelle was prepared using the hydrophilic polysaccharide, oligo-chitosan, and hydrophobic side chains, ursolic acid which assists the skin penetration, because the amphiphilic polysaccharide nanoparticles have been widely investigated as the carriers for active agents such as small molecules, proteins, peptides, and nucleic acids due to many advantages in prote...

A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(l-lysine) block copolymers (PEG-b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic l...

We present an in-silico-to-in-vitro approach to develop well-defined, self-assembled, rigid-cored polymeric (Polybee) nano-architecture for controlled delivery of a key component of bee venom, melittin. A competitive formulation with lipid-encapsulated (Lipobee) rigid cored micelle is also synthesized. In a series of sequential experiments, we show how nanoscale chemistry influences the deliver...

Biodegradable polymeric micelles containing doxorubicin in the core region were prepared from a di-block copolymer composed of doxorubicin-conjugated poly(DL-lactic-co-glycolic acid) (PLGA) and polyethyleneglycol (PEG). The di-block copolymer of PLGA-PEG was first synthesized and the primary amino group of doxorubicin was then conjugated to the terminal hydroxyl group of PLGA, which had been pr...