The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...

The formation and physico-chemical properties of biomaterial, based on double-stranded (ds) DNA molecules and bearing high concentration of gadolinium, is described. This “rigid” biomaterial demonstrate a few unique properties: 1) the ds DNA molecules forming complexes with gadolinium are fixed in the spatial structure of “rigid” particles, 2) an abnormal negative band in the circular dichroism...

Silk is a natural polymer synthesized and secreted by specialized silk gland of the silk worm. Silk is evolved as an ideal biomaterial can provide functional insight into relationships between polymer science and molecular biology. Silk proteins can be recovered from the silk during the processing chain of textile manufacture. The important characteristic of silk, especially the biocompatibilit...

search between a Dutch group and a group in Chengdu, China,4,5 revealed that similar bone formation was seen with porous ceramics of various types of hydroxyapatite, tricalcium phosphate, and Bioglass® (NovaBone Products, Alachua, FL, USA). Fujibayashi and others in our department6 also reported that porous titanium processed with alkali-heat treatment has osteoinduction. This material contains...

Biomaterial scaffolds mimic aspects of the native central nervous system (CNS) extracellular matrix (ECM) and have been extensively utilized to influence neural cell (NC) behavior in in vitro and in vivo settings. These biomimetic scaffolds support NC cultures, can direct the differentiation of NCs, and have recapitulated some native NC behavior in an in vitro setting. However, NC transplant th...

background: surface properties of a biomaterial could be critical in determining biomaterial’s biocompatibility due to the fact that the first interactions between the biological environment and artificial materials are most likely occurred at material’s surface. in this study, the surface properties of a new nanocomposite (nc) polymeric material were modified by combining plasma treatment and ...

Mesenchymal stem cells (MSCs) have been recognized as the best candidate for tissue engineering, while the mechanism of biomaterial-induced MSCs differentiation is not well understood. Most of research has been focused on chemical signaling of biomaterial in the past, but a variety of non-chemical signals were also proved to play essential roles in cellular behaviors. In this paper, we reviewed...

Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product. Cell-biomaterial interaction is referred to here as the phenom...

background: a dressing often covers the wound to accelerate its healing. hydrocolloid-type dressing to give better conditions for healing has been developed consisting of gelatin, pectin, water and hydrophilic polymer which promote healing. in recent years, much attention has been focused on the research and development of polymer hydrogels as biomaterials, such as contact lenses, wound dressin...

Background: Surface properties of a biomaterial could be critical in determining biomaterial’s biocompatibility due to the fact that the first interactions between the biological environment and artificial materials are most likely occurred at material’s surface. In this study, the surface properties of a new nanocomposite (NC) polymeric material were modified by combining plasma treatment and...