Gene therapy is a promising strategy for treatment of genetically caused diseases. Successful gene delivery requires an efficient carrier to transfer the desired gene into host cells. Recently, mesoporous silica nanoparticles (MSNs) functionalized with 25 kD polyethyleneimine (PEI) were extensively used as gene delivery carriers. However, 25 kD PEI could significantly reduce the safety of the m...

Polyethyleneimine (PEI) is known for its metal-coordinating properties and in its crosslinked form has applications in different areas ranging from drug delivery to waste water treatment and recovery of trace metals. With the aim to regulate the coordination environment of Cu(I) and Cu(II) ions in marine coatings, we have prepared a triazole cross-linking agent with 'soft' coordination that can...

Engineering a safe and high-efficiency delivery system for efficient RNA interference is critical for successful gene therapy. In this study, we designed a novel nanocarrier system of polyethyleneimine (PEI)-modified Fe3O4@SiO2, which allows high efficient loading of VEGF small hairpin (sh)RNA to form Fe3O4@SiO2/PEI/VEGF shRNA nanocomposites for VEGF gene silencing as well as magnetic resonance...

Bone marrow stromal cells (BMSC) modified with therapeutic genes are being actively pursued for gene therapy protocols. To develop safe and effective nonviral methods for BMSC modification, the cationic polymer polyethyleneimine (PEI) has been utilized to condense plasmid DNA for intracellular delivery. This study was conducted to explore the feasibility of increasing the PEI's effectiveness by...

Abstract The interlayer spacing (i.e., d -spacing) plays a crucial role in determining the selectivity and permeability of nanofiltration membranes. A high-throughput directional filtration can be achieved by designing controlling -spacing. In this study, -spacing graphene oxide (GO) membrane was tuned fixed to desired value (approximately 0.79 nm) using solution polyethyleneimine (PEI) GO at P...

To improve the flame retardancy of bamboo materials, layer by (LbL) self-assembly phytic acid (PA)-polyethyleneimine (PEI) on surface shaving super specimens with different solution concentrations PA-PEI and times LbL was completed in this study. Fourier transform infrared analysis results showed that PEI well assembled to a hydrogen bond PA as intermediation. The application significantly prom...

A carboxymethyl cellulose (CMC)/polyethyleneimine (PEI) hybrid hydrogel was successfully prepared under green processing conditions. The CMC and PEI formed a polyelectrolyte complex, the three-dimensional (3D) network structure hardened by chemical crosslinking, resulting in suitable properties. In CMC/PEI hydrogel, surface charge easily switched according to pH change, swelling contraction rev...

An alginate gel bead composite adsorbent with polyethyleneimine (PEI) as a surface modifier and Eichhornia crassipes (EC) biochar, known EC-alg/PEI-3, was added internally to the adsorb Cr(VI) from an aqueous environment. The functionalized beads were characterized using SEM, XPS, FTIR, other techniques. maximum adsorption capacities of EC-alg/PEI-3 714.3 mg g?1 at 10 °C 769.2 25 °C. In treatme...

INTRODUCTION Inflammation in dental pulp cells (DPCs) initiated by Lipopolysaccharide (LPS) results in dental pulp necrosis. So far, whether there is a common system regulating inflammation response and tissue regeneration remains unknown. miR-146a is closely related to inflammation. Basic fibroblast growth factor (bFGF) is an important regulator for differentiation. METHODS To explore the ef...

We report the facile synthesis of arginine-glycine-aspartic acid (RGD) peptide-targeted iron oxide (Fe3O4) nanoparticles (NPs) with ultrahigh relaxivity for in vivo tumor magnetic resonance (MR) imaging. In this study, stable polyethyleneimine (PEI)-coated Fe3O4 NPs were first prepared by a mild reduction route. The formed aminated Fe3O4 NPs with PEI coating were sequentially conjugated with fl...