Transgenic (TG) female mice expressing bLHbeta-CTP (a chimeric protein derived from the beta-subunit of bovine luteinizing hormone [LH] and a fragment of the beta-subunit of human chorionic gonadotropin [hCG]) exhibit elevated serum LH, infertility, polycystic ovaries, and ovarian tumors. In humans, increased LH secretion also occurs in infertility and polycystic ovarian syndrome, often concomi...

background and objective: uterus of rat with polycystic ovary (pco) may show pathological features. we provided pathological evidence for the rat uterus with no-induced pco.    materials and methods: wistar rats (weighing 200-250 g) were kept diestrous to receive l-arginine (50 mg/kg) intraperitoneally (i.p.) for 9 days/once a day. control group solely received saline (1 ml/kg, 9 days/once per ...

Polycystic ovarian syndrome (PCOS) is a condition of unexplained hyperandrogenic chronic anovulation that most likely represents a heterogenous disorder. About 10% of women in the reproductive age group suffer from this disorder. Many adolescent girls and young adults seek consultation because of this disorder. It’s etiology is as yet undefined, and therapy remains largely symptomatic and empir...

Polycystic ovary syndrome is an endocrinological disorder where there is hyperandrogenism, ovarian dysfunction and multiple ovarian cysts. The most common presenting features are hirsutism, acne, metabolic syndrome and biochemical hyperandrogenism. Patients also have hyperlipidemia and an impaired glucose metabolism. Treatment involves oral contraceptive pills for menstrual abnormalities and hy...

Rubinstein-Taybi syndrome is characterized by mental retardation, atypical facial features, broad thumbs and toes, and scoliosis. Polycystic ovaries are associated with chronic anovulation and abnormal uterine bleeding. A 15-year old female patient was diagnosed with Rubinstein-Taybi Syndrome, and had prolonged abnormal uterine bleeding for 2 years, accompanied by a polycystic ovary. As she sho...

l p g ( N a Polycystic ovarian syndrome (PCOS) is considered the most common endocrine disorder among women of reproductive age, but prevalence estimates have varied from a low of 4.6% found by Knochenhauer et al in 1998 to a high of .8% noted by Diamanti-Kandarakis et l in 1999. Other estimates have fallen etween these ranges. The exact cause of PCOS still is unknown, but it is characterized b...

Two 21-year-old female twins are described. They presented simultaneously with hirsutism and oligomenorrhoea. Investigation showed they had polycystic ovaries, they were identical and were not cases of post-pubertal adrenogenital syndrome.

The polycystic ovary syndrome was diagnosed according to the following criteria: [1] bilateral polycystic ovaries on ultrasonography; [2] oligomenorrhea or amenorrhea, hirsutism, obesity, or chronic anovulation, or any combination of these conditions; [3] hyperandrogenemia (elevated serum levels of testosterone, free testosterone, or androstenedione); [4] elevated serum LH levels; and [5] exclu...

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various gen...