Autosomal dominant polycystic kidney disease (ADPKD) is characterized by abnormal proliferation of renal tubular epithelial cells, resulting in the loss of renal function. Despite identification of the genes responsible for ADPKD, few effective drugs are currently available for the disease. Thus finding additional effective drug targets is necessary. The functions of multidrug- resistance-assoc...

Polycystic Kidney Disease (PKD) is an autosomal recessive disease with an incidence of about 1 in 30,000 births. It characterized by multiple cysts which filled by fluid that can ultimately impede kidney function leading to degeneration of renal tissue and renal failure. Oligo or anhydramnios is frequently present but not invariably so, suggesting that some degree of renal function is retained ...

CONTEXT "Cystic degeneration" of the kidneys was first described pathologically in 1841 and "polycystic kidneys" as a clinical syndrome in 1888. The heritable nature in some families was noted in 1899, and autosomal dominant and recessive patterns of inheritance of polycystic kidney disease (PKD) were later recognised. Autosomal dominant PKD is one of the most common human genetic diseases and ...

autosomal dominant polycystic kidney disease (adpkd) is the most common form of inherited kidney disease that results in renal failure. pkd currently has no causative therapy. however, some treatment options are available, ranging from symptomatic therapy to delaying the onset of end-stage renal failure. early diagnosis of adult polycystic kidney disease is vital in order to prevent its complic...

Although water is essential for life, its use for medicinal purposes is not universally accepted. We performed a comprehensive review of the literature to determine where the evolving state of knowledge lies regarding the benefits of water as a therapy for renal diseases. In the past two decades, water has emerged as a potential therapeutic agent in nephrolithiasis, chronic kidney disease (CKD)...

Clear cell tubopapillary renal cell carcinoma (CCTP-RCC) is a distinct histologic subtype of RCC recognized for its unique clinicopathologic and immunohistochemical features. A 72-year-old man with presumed polycystic kidney disease (PKD) and bilateral clear cell RCC (CC-RCC) underwent left radical nephrectomy and right partial nephrectomy 20 years ago at an outside hospital. On surveillance im...

Autosomal dominant polycystic kidney disease (PKD) is a hereditary condition characterized by the progressive enlargement of innumerable renal cysts that contribute to life-altering morbidity early in the course of the disease. Evidence indicates that the rate of increase in kidney volume can be reliably measured by magnetic resonance or computed tomography imaging, thus providing objective mea...

The term polycystic kidney disease (PKD) has inappropriately been used to describe any kidney riddled with cysts(l). Polycystic kidney disease is a rare disorder and was seen in 16 patients whereas renal cysts occurred in 136 of 6521 consecutive autopsies in infants and children(2). The matter has been further complicated with the recognition of juvenile presentation of autosomal recessive(3) a...

Polycystic Kidney Disease (PKD) is an inherited disorder in which the anomalous composition of renal tubules results buildout multiple cysts within kidney. The genetic PKD mainly occurs between 30 to 40 years age but acquired can occur because obesity, persistent high blood pressure, irregular eating patterns, and a sedentary lifestyle at any stage life. severe side or back pain, abdomen fullne...

Autosomal dominant polycystic kidney disease (PKD) is a hereditary condition characterized by the progressive enlargement of innumerable renal cysts that contribute to life-altering morbidity early in the course of the disease. Evidence indicates that the rate of increase in kidney volume can be reliably measured by magnetic resonance or computed tomography imaging, thus providing objective mea...