نتایج جستجو برای: polyamide
تعداد نتایج: 3101 فیلتر نتایج به سال:
The design of molecules that damage a selected DNA sequence provides a formidable opportunity for basic and applied biology. For example, such molecules offer new prospects for controlled manipulation of the genome. The conjugation of DNA-code reading molecules such as polyamides to reagents that induce DNA damages provides an approach to reach this goal. In this work, we showed that a bipyridi...
Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole-imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polyamide targeting TMPRSS2-ERG translocation breakpoints and assessed its effect on human prostate ca...
In this study, acicular nano-hydroxyapatite (n-HA) was used to make a new biomimetic composite with polyamide (poly hexamethylene adipamide) by a unique technique. The physical and chemical characteristics of the composites were tested. It was found that these synthesized n-HA crystals were similar to bone apatite in size, phase composition and crystal structure. The biomimetic n-HA crystals we...
The Nucleosome Core Particle (NCP) is the minimal unit in eukaryotic chromatin and a unique target for DNA-binding polyamides. The ability to modulate the stability of nucleosomes would be a useful tool for molecular biology and gene regulation. A series of polyamide clamps designed to differentiate between the NCP and B-form DNA were synthesized and analyzed using DNase I footprinting. In addi...
Hydrogen bond directed folding of a synthetic polyamide was studied in chloroform solution, and the three-dimensional structure of the foldamer determined using 1H NMR chemical shifts.
BACKGROUND Gene-specific targeting of any protein-DNA complex by small molecules is a challenging goal at the interface of chemistry and biology. Polyamides containing N-methylimidazole and N-methylpyrrole amino acids are synthetic ligands that have an affinity and specificity for DNA comparable to many naturally occurring DNA-binding proteins. It has been shown that an eight-ring hairpin polya...
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